• 2025
  Cui G, Ley M, Mechaly AE, Bui LC, Michail C, Berthelet J, Dairou J, Yang H, Chevreux G, Moroy G, Green MR, Haouz A, Rodrigues Lima F, Structural and functional characterization of CREB-binding protein (CREBBP) as a histone propionyltransferase., J Biol Chem 2025 Jul; 301(8): 110444.
• 2025
  Dussouchaud M, Martinez-Carranza M, Garcia PS, Clémancey M, Blondin G, Betton JM, Haouz A, Gribaldo S, Ollagnier de Choudens S, Sauguet L, Mechaly A, Barras F, Ancestral [Fe-S] biogenesis system SMS has a unique mechanism of cluster assembly and sulfur utilization., PLoS Biol 2025 Jun; 23(6): e3003223.
• 2025
  Yang H, Zhang W, Ravanmehr V, Cui G, Bowman K, Chen R, Henderson J, Lockman SR, Rojas E, Wilson AL, Parsons S, Mechaly A, Regad L, Haouz A, Flowers CR, Neelapu SS, Nastoupil LJ, Davis RE, Deng Q, Rodrigues Lima F, Green MR, Blunted CD40-responsive enhancer activation in CREBBP-mutant lymphomas can be restored by enforced CD4 T-cell engagement., Blood 2025 Mar; (): .
• 2024
  Gedeon A, Yab E, Dinut A, Sadowski E, Capton E, Dreneau A, Petit J, Gioia B, Piveteau C, Djaout K, Lecat E, Wehenkel AM, Gubellini F, Mechaly A, Alzari PM, Deprez B, Baulard A, Aubry A, Willand N, Petrella S, Molecular mechanism of a triazole-containing inhibitor of Mycobacterium tuberculosis DNA gyrase., iScience 2024 Oct; 27(10): 110967.
• 2024
  Legru A, Batista FA, Puszko AK, Bouillon A, Maurel M, Martinez M, Ejjoummany A, Ortega Varga L, Adler P, Méchaly A, Hadjadj M, Sosnowski P, Hopfgartner G, Alzari PM, Blondel A, Haouz A, Barale JC, Hernandez JF, Insights from structure-activity relationships and the binding mode of peptidic α-ketoamide inhibitors of the malaria drug target subtilisin-like SUB1., Eur J Med Chem 2024 Apr; 269(): 116308.
• 2024
  David Fernandez-Martinez, Youxin Kong, Sylvie Goussard, Agustin Zavala, Pauline Gastineau, Martial Jean-Pierre Rey, Gabriel Ayme, Julia Chamot‐rooke, Pierre Lafaye, Matthijn Vos, Ariel Mechaly, Guillaume Duménil, Cryo-EM structures of type IV pili complexed with nanobodies reveal immune escape mechanisms, Nature Communications, 2024, 15 (1), pp.2414. ⟨10.1038/s41467-024-46677-y⟩.
• 2024
  Le Coadou L, Berthelet J, Mechaly AE, Michail C, Bui LC, Dairou J, Haouz A, Dupret JM, Rodrigues Lima F, Structural and enzymatic evidence for the methylation of the ACK1 tyrosine kinase by the histone lysine methyltransferase SETD2., Biochem Biophys Res Commun.
• 2024
  Zinke M, Lejeune M, Mechaly A, Bardiaux B, Boneca IG, Delepelaire P, Izadi-Pruneyre N, Ton motor conformational switch and peptidoglycan role in bacterial nutrient uptake., Nat Commun 2024 Jan; 15(1): 331.
• 2023
  Yang L, Wagner T, Mechaly A, Boyko A, Bruch EM, Megrian D, Gubellini F, Alzari PM, Bellinzoni M, High resolution cryo-EM and crystallographic snapshots of the actinobacterial two-in-one 2-oxoglutarate dehydrogenase., Nat Commun 2023 Aug; 14(1): 4851.
• 2023
  Gedeon A, Ayoub N, Brûlé S, Raynal B, Karimova G, Gelin M, Mechaly A, Haouz A, Labesse G, Munier-Lehmann H, Insight into the role of the Bateman domain at the molecular and physiological levels through engineered IMPDHs., Protein Sci 2023 Jun; (): e4703.
• 2023
  Dazzoni R, Li Y, López-Castilla A, Brier S, Mechaly A, Cordier F, Haouz A, Nilges M, Francetic O, Bardiaux B, Izadi-Pruneyre N, Structure and dynamic association of an assembly platform subcomplex of the bacterial type II secretion system., Structure 2023 Feb; 31(2): 152-165.e7.
• 2023
  Covaleda-Cortés G, Mechaly A, Brissac T, Baehre H, Devaux L, England P, Raynal B, Hoos S, Gominet M, Firon A, Trieu-Cuot P, Kaminski PA, , The c-di-AMP-binding protein CbpB modulates the level of ppGpp alarmone in Streptococcus agalactiae., FEBS J 2023 Jan; (): .
• 2023
  Genera M, Colcombet-Cazenave B, Croitoru A, Raynal B, Mechaly A, Caillet J, Haouz A, Wolff N, Caillet-Saguy C, Interactions of the protein tyrosine phosphatase PTPN3 with viral and cellular partners through its PDZ domain: insights into structural determinants and phosphatase activity., Front Mol Biosci 2023 ; 10(): 1192621.
• 2022
  Léger C, Pitard I, Sadi M, Carvalho N, Brier S, Mechaly A, Raoux-Barbot D, Davi M, Hoos S, Weber P, Vachette P, Durand D, Haouz A, Guijarro JI, Ladant D, Chenal A, , Dynamics and structural changes of calmodulin upon interaction with the antagonist calmidazolium., BMC Biol 2022 08; 20(1): 176.
• 2022
  Walter P, Mechaly A, Bous J, Haouz A, England P, Lai-Kee-Him J, Ancelin A, Hoos S, Baron B, Trapani S, Bron P, Labesse G, Munier-Lehmann H, , Structural basis for the allosteric inhibition of UMP kinase from Gram-positive bacteria, a promising antibacterial target., FEBS J 2022 Feb; (): .
• 2022
  Zhu Y, Alvarez F, Wolff N, Mechaly A, Brûlé S, Neitthoffer B, Etienne-Manneville S, Haouz A, Boëda B, Caillet-Saguy C, , Interactions of Severe Acute Respiratory Syndrome Coronavirus 2 Protein E With Cell Junctions and Polarity PSD-95/Dlg/ZO-1-Containing Proteins., Front Microbiol 2022 ; 13(): 829094.
• 2021
  Nian Q, Berthelet J, Parlato M, Mechaly AE, Liu R, Dupret JM, Cerf-Bensussan N, Haouz A, Rodrigues Lima F, , Structural characterization of a pathogenic mutant of human protein tyrosine phosphatase PTPN2 (Cys216Gly) that causes very early onset autoimmune enteropathy., Protein Sci 2021 Nov; (): .
• 2021
  Voegele A, Sadi M, O'Brien DP, Gehan P, Raoux-Barbot D, Davi M, Hoos S, Brûlé S, Raynal B, Weber P, Mechaly A, Haouz A, Rodriguez N, Vachette P, Durand D, Brier S, Ladant D, Chenal A, , A High-Affinity Calmodulin-Binding Site in the CyaA Toxin Translocation Domain is Essential for Invasion of Eukaryotic Cells., Adv Sci (Weinh) 2021 05; 8(9): 2003630.
• 2021
  Genera M, Quioc-Salomon B, Nourisson A, Colcombet-Cazenave B, Haouz A, Mechaly A, Matondo M, Duchateau M, König A, Windisch MP, Neuveut C, Wolff N, Caillet-Saguy C, , Molecular basis of the interaction of the human tyrosine phosphatase PTPN3 with the hepatitis B virus core protein., Sci Rep 2021 Jan; 11(1): 944.
• 2020
  Zhu Y, Delhommel F, Cordier F, Lüchow S, Mechaly A, Colcombet-Cazenave B, Girault V, Pepermans E, Bahloul A, Gautier C, Brûlé S, Raynal B, Hoos S, Haouz A, Caillet-Saguy C, Ivarsson Y, Wolff N, , Deciphering the Unexpected Binding Capacity of the Third PDZ Domain of Whirlin to Various Cochlear Hair Cell Partners., J Mol Biol 2020 11; 432(22): 5920-5937.
• 2020
  Cheung YW, Röthlisberger P, Mechaly AE, Weber P, Levi-Acobas F, Lo Y, Wong AWC, Kinghorn AB, Haouz A, Savage GP, Hollenstein M*, Tanner JA*, , Evolution of abiotic cubane chemistries in a nucleic acid aptamer allows selective recognition of a malaria biomarker., Proc. Natl. Acad. Sci. U.S.A. 2020 Jul; (): .
• 2020
  Gibson KH, Trajtenberg F, Wunder EA, Brady MR, San Martin F, Mechaly A, Shang Z, Liu J, Picardeau M, Ko A, Buschiazzo A, Sindelar CV, , An asymmetric sheath controls flagellar supercoiling and motility in the leptospira spirochete., Elife 2020 Mar; 9(): .
• 2019
  Weber P, Pissis C, Navaza R, Mechaly AE, Saul F, Alzari PM, Haouz A, High-Throughput Crystallization Pipeline at the Crystallography Core Facility of the Institut Pasteur, Molecules 2019 Dec;24(24).
• 2019
  Grillová L, Oppelt J, Mikalová L, Nováková M, Giacani L, Niesnerová A, Noda AA, Mechaly AE, Pospíšilová P, Čejková D, Grange PA, Dupin N, Strnadel R, Chen M, Denham I, Arora N, Picardeau M, Weston C, Forsyth RA, Šmajs D, Directly Sequenced Genomes of Contemporary Strains of Syphilis Reveal Recombination-Driven Diversity in Genes Encoding Predicted Surface-Exposed Antigens, Front Microbiol 2019;10:1691.
• 2018
  Mechaly AS, Tovar Bohórquez MO, Mechaly AE, Suku E, Pérez MR, Giorgetti A, Ortí G, Viñas J, Somoza GM, Evidence of Alternative Splicing as a Regulatory Mechanism for Kissr2 in Pejerrey Fish, Front Endocrinol (Lausanne) 2018;9:604.
• 2018
  Mechaly AE, Haouz A, Sassoon N, Buschiazzo A, Betton JM, Alzari PM, Conformational plasticity of the response regulator CpxR, a key player in Gammaproteobacteria virulence and drug-resistance, J. Struct. Biol. 2018 Nov;204(2):165-171.
• 2018
  Jacob-Dubuisson F, Mechaly A, Betton JM, Antoine R, Structural insights into the signalling mechanisms of two-component systems, Nat. Rev. Microbiol. 2018 Jul;.
• 2018
  Adhikarla H, Wunder EA, Mechaly AE, Mehta S, Wang Z, Santos L, Bisht V, Diggle P, Murray G, Adler B, Lopez F, Townsend JP, Groisman E, Picardeau M, Buschiazzo A, Ko AI, Lvr, a Signaling System That Controls Global Gene Regulation and Virulence in Pathogenic, Front Cell Infect Microbiol 2018;8:45.
• 2017
  Imelio JA, Larrieux N, Mechaly AE, Trajtenberg F, Buschiazzo A, , Snapshots of the Signaling Complex DesK:DesR in Different Functional States Using Rational Mutagenesis and X-ray Crystallography., Bio Protoc 2017 Aug; 7(16): e2510.
• 2017
  Mechaly AE, Soto Diaz S, Sassoon N, Buschiazzo A, Betton JM, Alzari PM, Structural Coupling between Autokinase and Phosphotransferase Reactions in a Bacterial Histidine Kinase, Structure 2017 Jun;25(6):939-944.e3.
• 2017
  San Martin F, Mechaly AE, Larrieux N, Wunder EA, Ko AI, Picardeau M, Trajtenberg F, Buschiazzo A, Crystallization of FcpA from Leptospira, a novel flagellar protein that is essential for pathogenesis, Acta Crystallogr F Struct Biol Commun 2017 03;73(Pt 3):123-129.
• 2016
  Trajtenberg F, Imelio JA, Machado MR, Larrieux N, Marti MA, Obal G, Mechaly AE, Buschiazzo A, Regulation of signaling directionality revealed by 3D snapshots of a kinase:regulator complex in action, Elife 2016 12;5.
• 2016
  Fouts DE, Matthias MA, Adhikarla H, Adler B, Amorim-Santos L, Berg DE, Bulach D, Buschiazzo A, Chang YF, Galloway RL, Haake DA, Haft DH, Hartskeerl R, Ko AI, Levett PN, Matsunaga J, Mechaly AE, Monk JM, Nascimento AL, Nelson KE, Palsson B, Peacock SJ, Picardeau M, Ricaldi JN, Thaipandungpanit J, Wunder EA, Yang XF, Zhang JJ, Vinetz JM, What Makes a Bacterial Species Pathogenic?:Comparative Genomic Analysis of the Genus Leptospira, PLoS Negl Trop Dis 2016 Feb;10(2):e0004403.
• 2015
  East A, Mechaly AE, Huysmans GHM, Bernarde C, Tello-Manigne D, Nadeau N, Pugsley AP, Buschiazzo A, Alzari PM, Bond PJ, Francetic O, Structural Basis of Pullulanase Membrane Binding and Secretion Revealed by X-Ray Crystallography, Molecular Dynamics and Biochemical Analysis, Structure 2016 Jan;24(1):92-104.
• 2014
  Trajtenberg F, Albanesi D, Ruétalo N, Botti H, Mechaly AE, Nieves M, Aguilar PS, Cybulski L, Larrieux N, de Mendoza D, Buschiazzo A, Allosteric activation of bacterial response regulators: the role of the cognate histidine kinase beyond phosphorylation, MBio 2014 Nov;5(6):e02105.
• 2014
  Correa A, Pacheco S, Mechaly AE, Obal G, Béhar G, Mouratou B, Oppezzo P, Alzari PM, Pecorari F, Potent and specific inhibition of glycosidases by small artificial binding proteins (affitins), PLoS ONE 2014;9(5):e97438.
• 2014
  Mechaly AE, Sassoon N, Betton JM, Alzari PM, Segmental helical motions and dynamical asymmetry modulate histidine kinase autophosphorylation, PLoS Biol. 2014 Jan;12(1):e1001776.
• 2012
  Mechaly AE, Bellomio A, Morante K, Agirre J, Gil-Cartón D, Valle M, González-Mañas JM, Guérin DM, Pores of the toxin FraC assemble into 2D hexagonal clusters in both crystal structures and model membranes, J. Struct. Biol. 2012 Nov;180(2):312-7.
• 2012
  Mechaly AE, Haouz A, Miras I, Barilone N, Weber P, Shepard W, Alzari PM, Bellinzoni M, , Conformational changes upon ligand binding in the essential class II fumarase Rv1098c from Mycobacterium tuberculosis., FEBS Lett 2012 Jun; 586(11): 1606-11.
• 2011
  Mechaly AE, Bellomio A, Gil-Cartón D, Morante K, Valle M, González-Mañas JM, Guérin DM, Structural insights into the oligomerization and architecture of eukaryotic membrane pore-forming toxins, Structure 2011 Feb;19(2):181-91.
• 2009
  Mechaly AE, Bellomio A, Morante K, González-Mañas JM, Guérin DM, Crystallization and preliminary crystallographic analysis of fragaceatoxin C, a pore-forming toxin from the sea anemone Actinia fragacea, Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2009 Apr;65(Pt 4):357-60.
• 2008
  Agirre J, Mechaly A, Cabo-Bilbao A, Guérin DM, A plate holder for non-destructive testing of mesophase crystallization assays, Eur. Biophys. J. 2008 Jul;37(6):871-7.
• 2006
  Cabo-Bilbao A, Spinelli S, Sot B, Agirre J, Mechaly AE, Muga A, Guérin DM, Crystal structure of the temperature-sensitive and allosteric-defective chaperonin GroELE461K, J. Struct. Biol. 2006 Sep;155(3):482-92.