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© Research
Project

Structural basis and functional outcomes of epi-transcriptomic modifications of (+)RNA virus genomes

Scientific Fields
Diseases
Organisms
Applications
Technique
Starting Date
09
Dec 2020
Status
Ongoing
Members
1
Structures
1

About

Our project proposes to address, in vitro and in cells infected with Flaviviruses and Coronaviruses, the mechanisms by which enzymes forming the replication transcription complexes i) replicate and transcribe faithfully the RNA genome, ii) mark viral RNA by methylating the RNA nucleotides or the 5’ end cap structure to escape from detection by host cell antiviral sensors, iii) regulate genome evolution by controlling the fidelity of replication.

Fundings