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© Emeline Camand
Marquage par immunofluorescence d'astrocytes tumoraux ou astrocytomes (lignée cellulaire humaine U373), montrant en rouge, APC et en vert, la tubuline des microtubules. APC est un supresseur de tumeur qui est impliqué dans la polarisation des astrocytes normaux. La localisation d'APC est altérée dans des lignées de gliomes. Pour essayer de corriger, les dérèglements observés lors de la migration des cellules d'astrocytes tumuraux ou gliomes on cherche à connaitre les mécanismes moléculaires fondamentaux qui controlent la polarisation et la migration cellulaire.
Scientific Fields
Diseases
Organisms
Applications
Technique

About

Vanessa joined the lab in 2013 as a molecular/cell biology technician. Together with Gantas Perez-Mockus, she is studying the role of the E3 ubiquitin ligase Neuralized in epithelial morphogenesis, looking more specifically at the molecular targets of Neuralized.

Projects

Project
Ongoing
6 Members

Cytoskeleton and Mechanobiology projects

Sandrine Etienne-Manneville (PI)

Until now, the role of actin in cell migration has been extensively studied, but much less is known about the role of microtubules and Intermediate Filaments(IFs) (Dutour-Provenzano and Etienne-Manneville, 2021, 34033784; Etienne-Manneville, 2018, 30059630). […]
Project
Ongoing
6 Members

Cell Polarity projects

Sandrine Etienne-Manneville (PI)

  What are the central components of polarity pathways ? Are they affected during gliomagenesis? Using astrocyte directed migration as a model system, we have identified evolutionary conserved polarity signals that control cell polarity […]
Project
Ongoing
5 Members

Epithelial morphogenesis

François Schweisguth (PI)

Epithelia form sheets of interconnected cells that are polarized along an apical-basal axis and perform selective exchange and barrier functions. Epithelia are dynamic structures that undergo remodeling associated with cell shape changes and neighbor […]

Publications

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