I’m currently a postdoctoral researcher in the Insect Immunity & Infection group within the Virology Department and the Insect-Virus Interactions Unit. We aim to understand the interactions between Aedes aegypti mosquitoes and the arboviruses they transmit to humans (i.e. dengue virus, Zika virus and Chikungunya virus). My research focuses particularly on understanding the molecular mechanisms behind the natural resistance or susceptibility of field-derived mosquito colonies to dengue viruses, using approaches that combine metabolomics and single-cell omics.
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Timeline
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Academic education
2017-2020 PhD Degree in Virology, Université Toulouse III, Paul Sabatier, France / Duke-NUS Medical School, Singapore
2008-2010 Master Degree in Cellular and Molecular biology, Université Pierre et Marie Curie, Paris IV, France
2005-2008 Bachelor Degree in Microbiology, Université Claude Bernard, Lyon 1, France
Research experience
Since January 2022 Post-doctoral researcher within the Interactions Virus-Insect Unit, Virology department, Institut Pasteur, CNRS UMR 2000
November 2020 – November 2021 Post-doctoral researcher Department of pathology, Division of Virology, University of Cambridge, Cambridge, United-Kingdom /AMC Medical Research, Amsterdam UMC, Amsterdam, Netherland. Supervisor: Dr. AJ te Velthius, Project: Study of emerging mutations and inhibitors impact on coronavirus replication by the establishment of a virus-free high-throughput platform.
September 2017 – June 2020 PhD student Duke-NUS Medical Shool, Singapore / PharmaDev, Faculté de pharmacie, Université de Touloue 3, France. Supervisor: Dr. Julien Pompon / Dr. Eric Deharo/ Dr. Guillaume Marti. Project: Study of the metabolic interactions between Dengue virus and mosquitoes using a metabolomic approach to identify host targets in order to limit viral transmission
January 2016 – December 2017 Scientific cooperation officer Institut de Recherche pour le Développement (IRD), Vientiane, Laos. Supervisor: Dr. Eric Deharo. Project: Coordination of interdisciplinary research projects on emerging infectious diseases in Laos, Singapore and Colombia.
March 2012- December 2015 Project manager / Immunology Team Leader Diagnostica Stago, Paris, France. Project: In charge of the development of the immunological reagent for the diagnosis of venous thromboembolic diseases.
Januray 2010- December 2011 Master – 2nd research internship / Research Associate in Virology Sanofi-Pasteur, Lyon, France. Project: Study the attenuation of flavivirus vaccine strains and immunization potential of vaccine candidates.
January – March 2009 Master – 1st research internship GIMAP, Université de Saint-Etienne, France. Supervisor: Dr. Bruno Pozetto. Project: In vitro evaluation of the benefit-risk effects of anti-HIV microbicides under vaginal epithelium.
Fellowships and Awards
2023 ACME Postdoc Travel Award
2023 Marie Skłodowska-Curie Actions Postdoctoral Fellowship
2022 Pasteur-Roux Post-doctoral Fellowship Grant
2018 PHC Merlion travel grant NUS Singapore – France
Publications
Link pubmed: https://pubmed.ncbi.nlm.nih.gov/?term=Vial+Thomas
Publications
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2021Enisamium Inhibits SARS-CoV-2 RNA Synthesis., Biomedicines 2021 Sep; 9(9): .
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2021Lipid Interactions Between Flaviviruses and Mosquito Vectors., Front Physiol 2021 ; 12(): 763195.
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2020Mosquito metabolomics reveal that dengue virus replication requires phospholipid reconfiguration via the remodeling cycle., Proc Natl Acad Sci U S A 2020 Nov; 117(44): 27627-27636.
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2020JNK pathway restricts DENV2, ZIKV and CHIKV infection by activating complement and apoptosis in mosquito salivary glands., PLoS Pathog 2020 Aug; 16(8): e1008754.
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2019Dengue virus reduces AGPAT1 expression to alter phospholipids and enhance infection in Aedes aegypti., PLoS Pathog 2019 Dec; 15(12): e1008199.
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2018Hepatitis C in Laos: A 7-Year Retrospective Study on 1765 Patients., Virol Sin 2018 Aug; 33(4): 295-303.
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2018A Seven-Year Retrospective Study on the Surveillance of Hepatitis B in Laos, International Journal of Hepatology, 2018, 2018, pp.1-11. ⟨10.1155/2018/9462475⟩.
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2018Zika virus infection modulates the metabolomic profile of microglial cells., PLoS One 2018 ; 13(10): e0206093.
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2017A Zika virus from America is more efficiently transmitted than an Asian virus by Aedes aegypti mosquitoes from Asia., Sci Rep 2017 Apr; 7(1): 1215.