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© Institut Pasteur
Phlébotome. Petit diptère de la famille des psychodidés (dans l'Ancien Monde). La femelle hématophage peut être vectrice entre autres de leishmaniose qu'elle transmet par piqûre à un vertébré, chien (hôte principal réservoir), homme ou encore rat (hôtes occasionnels).
Scientific Fields
Diseases
Organisms
Applications
Technique

About

I am a permanent researcher in the Saleh lab. I obtained my PhD from the University of Padova (Italy), where I first fell in love with insects and their immune systems. During my doctoral studies, I investigated the genetic basis of antibacterial immunity in the silkworm.

In 2017, I joined Mathilde Gendrin’s group at the Institut Pasteur de la Guyane, where I began working on mosquitoes and their microbiota. During my time in Cayenne, I developed a method to rear germ-free mosquitoes, which I used to better understand how bacteria contribute to mosquito larval development. In parallel, I took part in several field missions to collect wild mosquitoes and characterize their natural microbiota.

In 2021, I joined Carla Saleh’s lab, initially exploring whether the mosquito microbiota could be leveraged to stimulate antiviral immunity against arboviruses. I demonstrated that the microbiota is not a suitable vehicle for delivering RNA molecules to mosquitoes. For this reason, my research now focuses on using insect-specific viruses as platforms to immunize mosquitoes against arboviruses. Additionally, I am carrying out two complementary projects: (1) investigating how the bacterial microbiota influences mosquito physiology and susceptibility to arboviral infection, and (2) characterizing how RNA interference regulates microbiota load and composition in mosquitoes and fruit flies.

Outside the lab, I enjoy spending time with my family, cooking (and eating!) Italian food, and doing arts and crafts.

CV

Research experience

Jan 2025-Today, Permanent scientist: Microbiota and RNA interference in mosquitoes
Institut Pasteur, Paris (France)
Virus and RNA Interference Group – Maria Carla Saleh

Sept 2021–Dec 2024, Postdoctoral fellow: Microbiota and RNA interference in mosquitoes
Institut Pasteur, Paris (France)
Virus and RNA Interference Group – Maria Carla Saleh

Nov 2017–Feb 2021, Postdoctoral fellow: Mosquito microbiota
Institut Pasteur de la Guyane, Cayenne (French Guiana)
Microbiota of Insect Vectors Group – Mathilde Gendrin

Jun 2016–Sept 2017, Postdoctoral fellow: Silkworm antibacterial immunity
University of Padova (Italy)
Federica Sandrelli’ lab

March–Dec 2016, Visiting scientist: Production of peptides using cell-free synthesis
Institut de Biologie Physico-Chimique, Paris (France)
Laboratoire de Biologie Physico-Chimique des Protéines Membranaires – Francesca Zito, Federica Sandrelli

May–Dec 2012, Research Assistant: Metagenomics of Anammox microorganisms
University of Padova (Italy)
Giorgio Valle’s and Andrea Squartini’s groups

Education

Jan 2013–Apr 2016, PhD in Biosciences and Biotechnology
University of Padova (Italy) – Federica Sandrelli’s group.
Thesis title: “Antimicrobial peptide-mediated immune response in four Bombyx mori strains infected with Gram-positive and -negative pathogens”.

Oct 2009–Oct 2011, Master’s degree in Industrial Biotechnology
University of Padova (Italy)

Oct 2006–Jul 2009, Bachelor’s degree in Biotechnology
University of Padova (Italy)

Sept 2001–Jul 2006
, High school Scientific Diploma
Liceo Duca degli Abruzzi, Treviso (Italy)

Publications

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