Expansion of the genetic alphabet with metal base pairs
Expanding the genetic code beyond the A-T/G-C Watson-Crick canonical base pairs and 20 amino acids of natural organisms is a long standing goal in synthetic biology. Reprogrammation of the genetic code can lead to […]
Therapeutic tools based on nucleic acids
An important research axis of the laboratory is to modify nucleic acids with chemical groups in order to improve their therapeutic usefulness. Particularly, modified aptamers (i.e. oligonucleotides capable of binding to targets with high […]
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2020Enzymatic Construction of Artificial Base Pairs: The Effect of Metal Shielding, ChemBioChem 2020, 21, 3398-3409.
2019Enzymatic Formation of an Artificial Base Pair Using a Modified Adenine Nucleoside Triphosphate, ChemRxiv 2019, doi: 10.26434/chemrxiv.11427459.v1.
2019Chemical methods for the modification of RNA, Methods 2019, 161, 64-82.
2018Applications of Ruthenium Complexes Covalently Linked to Nucleic Acid Derivatives, Molecules, 2018, 23, 1515.