Inés received her PhD in Cancer Research, Biomedicine and Cellular Biology from the University of Oviedo at the Institute of Sanitary Research of Principado de Asturias (ISPA) (Spain) in 2017. During her graduated work she focused on relevant aspects of tumor cell migration and invasion in Head and neck squamous cell carcinomas (HNSCC): the interaction of tumor cells with the tumor microenvironment and with other cells within the tumor mass. She had also the opportunity to collaborate in the development of BODIPY-carnitine probe allows monitoring the function and activity of mitochondria in living cells number of patent 18827960.8-1109 PCT/ES2018070477.
Now in the Zurzolo´s lab Inés is working in elucidate the role of tunneling nanotubes between glioblastoma stem cells and astrocytes in the resistance to treatment, recurrence and progression of Glioblastoma. To this aim, she is using 3D co-cultures as a model to mimic the conditions in the patient. Her major interest is to assess the metabolic implication of the transfer of mitochondria in the mechanism of resistance to treatment.
She is very artistic and appasionated in microscopy for this reason she is always looking for the perfect picture.
SCIENTIFIC PUBLICATIONS
– Sáenz-de-Santa-María I, Celada L, Chiara MD. The Leader Position of Mesenchymal Cells Expressing N-Cadherin in the Collective Migration of Epithelial Cancer. Cells. 2020 Mar 16;9(3):731.
doi: 10.3390/cells9030731.
-Sáenz-de-Santa-María I, Bernardo-Castiñeira C, Enciso E, García-Moreno I, Chiara JL, Suarez C, Chiara MD. Control of long-distance cell-to-cell communication and autophagosome transfer in squamous cell carcinoma via tunneling nanotubes. Oncotarget. 2017 Mar 28; 8(13):20939-20960. doi: 10.18632/oncotarget.15467. http://www.ncbi.nlm.nih.gov/pubmed/28423494.
-Sáenz-de-Santa-María I, Bernardo-Castiñeira C, Secades P, Bernaldo-de-Quirós S, Rodrigo JP, Astudillo A, Chiara MD. Clinically relevant HIF-1α-dependent metabolic reprogramming in oropharyngeal squamous cell carcinomas includes coordinated activation of CAIX and the miR-210/ISCU signaling axis, but not MCT1 and MCT4 upregulation. Oncotarget. 2017 Feb 21; 8(8):13730-13746. doi: 10.18632/oncotarget. 14629. http://www.ncbi.nlm.nih.gov/pubmed/28099149
-Blázquez-Moraleja A., Sáenz-de-Santa-María I., Chiara MD., Álvarez-Fernández D., García-Moreno I., Prieto Montero R., Martínez-Martínez V., López Arbeloa I., Chiara JL. Shedding light on the mitochondrial matrix through a functional membrane transporter. Chemical Science 2020.
-Carella A., Tejedor JR., García MG, UrdinguioRG, Bayón GF., Sierra M., López V., García-Toraño E., Santamarina-Ojeda P., Pérez RF., Bigot T., Mangas C., Corte-Torres MD., Sáenz-de-Santa-María I., Mollejo M., Meléndez B., Astudillo A., Chiara MD., Fernández AF and Fraga MF. Epigenetic downregulation of TET3 reduces genome-wide 5hmC levels and promotes glioblastoma tumorigenesis. International Journal of Cancer 2019.
-Blázquez-Moraleja A., Álvarez-Fernández D., Prieto Montero R., García-Moreno I., Martínez-Martínez V., Bañuelos J., Sáenz-de-Santa-María I., Chiara MD., Chiara JL. A general modular approach for the solubility tagging of BODIPY dyes. Dyes and Pigments 2019 Nov Volume 170, 107545https://doi.org/10.1016/j.dyepig.2019.107545
-Urdinguio RG† Lopez V†, Bayon GF, Diaz de la Guardia R, Sierra MI, Garcia-Torano E, Perez RF, Garcia MG, Carella A, Pruneda PC, Prieto C, Dmitrijeva M, Santamarina P, Belmonte T, Mangas C, Diaconu E, Ferrero C, Tejedor JR, Fernandez-Morera JL, Bravo C, Bueno C, Sanjuan-Pla A, Rodriguez RM, Suarez-Alvarez B, Lopez-Larrea C, Bernal T, Colado E, Balbin M, Garcia-Suarez O, Chiara MD, Saenz-de-Santa-Maria I, Rodriguez F, Pando-Sandoval A, Rodrigo L, Santos L, Salas A, Vallejo-Diaz J, Carrera AC, Rico D, Hernandez-Lopez I, Vaya A., Ricart JM, Seto E, Sima-Teruel N, Vaquero A., Valledor L, Canal MJ., Pisano D, Grana O, Thomas T, Voss AK, Menendez P, Villar-Garea A, Deutzmann R, Fernandez AF, Fraga MF. Chromatin regulation by Histone H4 acetylation at Lysine 16 during cell death and differentiation in the myeloid compartment. Nucleic Acids Res. 2019 pii: gkz195. http://www.ncbi.nlm.nih.gov/pubmed/30923829
-Bernardo-Castiñeira C, Sáenz-de-Santa-María I, Valdés N, Astudillo A, Balbín M, Pitiot AS, Jiménez-Fonseca P, Scola B, Tena I, Molina-Garrido MJ, Sevilla MA, Beristein E, Forga L, Villabona C, Oriola J, Halperin I, Suarez C, Chiara MD. Clinical significance and peculiarities of succinate dehydrogenase B and hypoxia inducible factor 1α expression in parasympathetic versus sympathetic paragangliomas. Head Neck. 2019 Jan; 41(1):79-91. doi: 10.1002/hed.25386. http://www.ncbi.nlm.nih.gov/pubmed/30549360
-García MG, Carella A, Urdinguio RG, Bayón GF, Lopez V, Tejedor JR, Sierra MI, García-Toraño E, Santamarina P, Perez RF, Mangas C, Astudillo A, Corte-Torres MD, Sáenz-de-Santa-María I, Chiara MD, Fernández AF, Fraga MF. Epigenetic dysregulation of TET2 in human glioblastoma. Oncotarget. 2018 May 25; 9(40):25922-25934. doi: 10.18632/oncotarget.25406. http://www.ncbi.nlm.nih.gov/pubmed/29899831
-Bernardo-Castiñeira C, Valdés N, Sierra MI, Sáenz-de-Santa-María I, Bayón GF, Perez RF, Fernández AF, Fraga MF, Astudillo A, Menéndez R, Fernández B, del Olmo M, Suarez C and Chiara MD. SDHC Promoter Methylation, a Novel Pathogenic Mechanism in Parasympathetic Paragangliomas. J Clin Endocrinol Metab. 2018 Jan1; 103(1):295-305. doi: 10.1210/jc.2017-01702. http://www.ncbi.nlm.nih.gov/pubmed/29126304
-Merlo A, Bernardo-Castiñeira C, Sáenz-de-Santa-María I, Pitiot AS, Balbín M, Astudillo A, Valdés N, Scola B, Del Toro R, Méndez-Ferrer S, Piruat JI, Suarez C, Chiara MD. Role of VHL, HIF1A and SDH on the expression of miR-210: Implications for tumoral pseudo-hypoxic fate. Oncotarget. 2017 Jan 24; 8(4):6700-6717. doi: 10.18632/oncotarget. 14265. http://www.ncbi.nlm.nih.gov/pubmed/28036268
-Arto T, Sáenz de Santa-María I, Chiara MD, Fañanás FJ, Rodríguez F. Berkelic Acid: Straightforward Analogue Synthesis and Studies of Activity Against Selected Cancer Cell Lines. Eur. J. Org. Chem. 2016: 5876–5880. doi:10.1002/ejoc.201601194. https://doi.org/10.1002/ejoc.201601194
-Secades P, de Santa-María IS, Merlo A, Suarez C, Chiara MD. In vitro study of normoxic epidermal growth factor receptor–induced hypoxia-inducible factor-1-alpha, vascular endothelial growth factor, and BNIP3 expression in head and neck squamous cell carcinoma cell lines: Implications for anti–epidermal growth factor receptor therapy. Head Neck. 2015 Aug; 37(8):1150-62. doi: 10.1002/hed.23733. http://www.ncbi.nlm.nih.gov/pubmed/24798801
-Merlo A, de Quirós SB, de Santa-María IS, Pitiot AS, Balbín M, Astudillo A, Scola B, Arístegui M, Quer M, Suarez C, Chiara MD. Identification of Somatic VHL Gene Mutations in Sporadic Head and Neck Paragangliomas in Association with Activation of the HIF-1α/miR-210 Signaling Pathway. J Clin Endocrinol Metab. 2013 Oct; 98(10):E1661-6. doi: 10.1210/jc.2013-1636. http://www.ncbi.nlm.nih.gov/pubmed/23902947
-Bernaldo de Quirós S, Merlo A, Secades P, Zambrano I, de Santa María IS, Ugidos N, Jantus-Lewintre E, Sirera R, Suarez C, Chiara MD. Identification of TRPC6 as a possible candidate target gene within an amplicon at 11q21-q22.2 for migratory capacity in head and neck squamous cell carcinomas. BMC Cancer 2013 Mar 14; 13:116. doi: 10.1186/1471- 2407-13-116. http://www.ncbi.nlm.nih.gov/pubmed/23497198