After two years of “classe préparatoire” at Lycée Sainte Geneviève, I started the “Magistère de Physico-chimie moléculaire” of the Ecole Normale Supérieure of Cachan-University Paris Saclay ans received the diploma of the Ecole Normale Supérieure of Cachan in September 2017. To finish this training I obtained with highest honours the master of molecular chemistry, sciences and engineering of the Ecole Polytechnique of Palaiseau in 2017. It is an international master’s degree in science that includes courses in organic chemistry, organometallic chemistry, chemical biology, medicinal and supramolecular chemistry as well as an education in industrial chemistry and management. I completed my training with a research tutoring under the supervision of Dr. Raphaël Rodriguez at the Institut Curie in Paris. I also received practical training in pharmaceutical and medical chemistry through internships, which were part of my academic background. I worked for four months in the Department of Medical Chemistry at the Royal College of Surgeons in Ireland in Dublin in Professor Donal O’Shea’s laboratory. I performed the synthesis and study of biocompatible fluorophore derivatives of azadipyrromethylene to improve the medical imaging of tissues during surgical procedures, particularly for an application in the ablation of colorectal cancer. I had to design a molecule with appropriate emission and absorption wavelengths to fit the medical machine available in surgical facilities. I had the opportunity to carry out my master thesis in chemistry, in the laboratory of Professor Chris Schofield at Oxford University, working on the study of antibiotic resistance based on a beta-lactam cycle. I synthesized some cephalosporin derivatives to inhibit the activity of metallo-beta-lactamase proteins. It is a hemi-synthetic work based on knowledge of the effects of the side chain on the stability and chemical structure of the protein target. I also developed small molecules derivatives as specific inhibitors of certain classes of Metallo-Bet- Lactamase. I obtained my Master 2 in Biology from Ecole Polytechnique in 2018 and completed it by a research intership in the Epigenetic Chemical Biology unit, Pasteur Institut under the supervision of Dr.Paola Arimondo. The goal of this internship being to characterize the activity of a new family of inhibitors in MLLr cells, comparing it to EPZ-5676,a molecule previously in clinical trials. I start in October my PhD under the supervision of Dr Paola Arimondo . My aim being the design and synthesis of a targeted library against epimethyltransferases.
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Epi-Med: synthesis and biological evaluation of new active molecules against MLL-rearranged leukaemia.
Paola Arimondo (PI)
Rearranged Mixed Lineage lLukaemia (MLLr) is a form of leukaemia representing approximately 75% of paediatric acute leukaemia and 10% of adult leukaemia (AML and ALL), with a very poor prognosis of survival at 5 […]
2020Bisubstrate inhibitors: the promise of a selective and potent chemical inhibition of epigenetic ‘writers’, Epigenomics, Sep. 2020.
2020Chapter 4 – Targeting DOT1L for mixed-lineage rearranged leukemia, Histone Modifications in Therapy, Translational Epigenetics 2020.
2019Espoirs et promesses de la méthylation de l’ADN et des histones comme cibles anticancéreuses, .
2019[Chemical targeting of DNA and histone methylation in cancer: Novelties, hopes and promises]., Bull Cancer 2019 Oct; 106(10): 823-833.
2019A Fluorescence‐Based Assay for Screening β‐Lactams Targeting the Mycobacterium tuberculosis Transpeptidase LdtMt2, ChemBioChem.
2018Structure activity relationship studies on rhodanines and derived enethiol inhibitors of metallo-β-lactamases, Bioorg. Med. Chem. 2018 07;26(11):2928-2936.
2017BF-azadipyrromethene NIR-emissive fluorophores with research and clinical potential, Eur J Med Chem 2017 Jul;135:392-400.