THE OTHER BOHR AND BIOLOGY's GREATEST MODEL - Research - Institut Pasteur

A little guide for advanced search:

Tip 1. You can use quotes "" to search for an exact expression.
Example: "cell division"
Tip 2. You can use + symbol to restrict results containing all words.
Example: +cell +stem
Tip 3. You can use + and - symbols to force inclusion or exclusion of specific words.
Example: +cell -stem

e.g. searching for members in projects tagged cancer

Search for

Count

IN

OUT

Content 1

Content Type

member
team
department
center
program_project
nrc
whocc
project
software
tool
patent

Keywords

Positions

Administrative Staff
Assistant Professor
Associate Professor
Clinical Research Assistant
Clinical Research Nurse
Clinician Researcher
Department Manager
Dual-education Student
Full Professor
Honorary Professor
Lab assistant
Master Student
Non-permanent Researcher
Nursing Staff
Permanent Researcher
Pharmacist
PhD Student
Physician
Post-doc
Prize
Project Manager
Research Associate
Research Engineer
Retired scientist
Technician
Undergraduate Student
Veterinary
Visiting Scientist

Appointments

Deputy Director of Center
Deputy Director of Department
Deputy Director of National Reference Center
Deputy Head of Facility
Director of Center
Director of Department
Director of Institute
Director of National Reference Center
Group Leader
Head of Facility
Head of Operations
Head of Structure
Honorary President of the Departement
Labex Coordinator

Content 2

Content Type

member
team
department
center
program_project
nrc
whocc
project
software
tool
patent

Keywords

Positions

Administrative Staff
Assistant Professor
Associate Professor
Clinical Research Assistant
Clinical Research Nurse
Clinician Researcher
Department Manager
Dual-education Student
Full Professor
Honorary Professor
Lab assistant
Master Student
Non-permanent Researcher
Nursing Staff
Permanent Researcher
Pharmacist
PhD Student
Physician
Post-doc
Prize
Project Manager
Research Associate
Research Engineer
Retired scientist
Technician
Undergraduate Student
Veterinary
Visiting Scientist

Appointments

Deputy Director of Center
Deputy Director of Department
Deputy Director of National Reference Center
Deputy Head of Facility
Director of Center
Director of Department
Director of Institute
Director of National Reference Center
Group Leader
Head of Facility
Head of Operations
Head of Structure
Honorary President of the Departement
Labex Coordinator

Search

EN
FR

Go back

Scroll to top

Phage Bacteria interactions in Clostridium difficile

THESE DE DOCTORAT

Scientific Fields

Diseases

Organisms

Applications

Technique

Date

03

Nov 2015

Time

00:00:11

25 Rue du Docteur Roux, Paris, France

Address

Building: Auditorium Centre François Jacob

Location

2015-11-03 00:00:11 2015-11-03 Europe/Paris THE OTHER BOHR AND BIOLOGY’s GREATEST MODEL Séminaire Département Neuroscience Mardi 3 Novembre 2015 à 11h30Auditorium Centre François Jacob Pr Rob PHILIPPSFred and Nancy Morris Professor of Biophysics and BiologyCalifornia Institute of Technology , CA, USA « The Other Bohr and […] 25 Rue du Docteur Roux, Paris, France Denise Derhy denise.derhy@pasteur.fr

About

Séminaire Département Neuroscience
Mardi 3 Novembre 2015 à 11h30
Auditorium Centre François Jacob

Pr Rob PHILIPPS
Fred and Nancy Morris Professor of Biophysics and Biology
California Institute of Technology , CA, USA

« The Other Bohr and Biology’s Greatest Model »

Invité par Jean-Pierre Changeux – Contact : jean-pierre.changeux@pasteur.fr

Abstract
We recently celebrated the 50th anniversary of a classic paper of Monod, Changeux and Jacob on allostery, a concept that is sometimes referred to as “the second secret of life”. That important paper was followed shortly thereafter by a second one that revealed their musings on how simple statistical mechanical models can be used to capture how such allosteric transitions work mechanistically. In this talk, I will review the key features of the famed Monod-Wyman-Changeux (MWC) model and then describe its broad reach across many different domains of biology with special reference to ion channels and other membrane receptors. One of the intriguing outcomes of this class of models is a beautiful scheme for collapsing data from entire libraries of mutants. Once we have considered some of the traditional uses of the MWC model, I will turn to more speculative recent ideas which use the MWC approach to consider DNA accessibility in chromatin and the nature of kinetic proofreading.

Location

Building: Auditorium Centre François Jacob
Address: 25 Rue du Docteur Roux, Paris, France

Published on: 02 Nov 2015

(function($) { /* * render_map * * This function will render a Google Map onto the selected jQuery element * * @type function * @date 8/11/2013 * @since 4.3.0 * * @param $el (jQuery element) * @return n/a */ function render_map( $el ) { var MY_MAPTYPE_ID = 'custom_style'; var featureOpts = [{"stylers":[{"hue":"#0088ff"}]}]; var styledMapOptions = { name: 'Custom Style' }; var customMapType = new google.maps.StyledMapType(featureOpts, styledMapOptions); // var var $markers = $el.find('.marker'); // vars var args = { zoom : 16, scrollwheel : false, center : new google.maps.LatLng(0, 0), mapTypeId : google.maps.MapTypeId.ROADMAP, mapTypeId : MY_MAPTYPE_ID }; // create map var map = new google.maps.Map( $el[0], args); map.mapTypes.set(MY_MAPTYPE_ID, customMapType); // add a markers reference map.markers = []; // add markers $markers.each(function(){ add_marker( $(this), map ); }); // center map center_map( map ); } /* * add_marker * * This function will add a marker to the selected Google Map * * @type function * @date 8/11/2013 * @since 4.3.0 * * @param $marker (jQuery element) * @param map (Google Map object) * @return n/a */ function add_marker( $marker, map ) { // var var latlng = new google.maps.LatLng( $marker.attr('data-lat'), $marker.attr('data-lng') ); //var image = 'https://research.pasteur.fr/wp-content/themes/biologyx2/images/logomap.png'; var myIcon = new google.maps.MarkerImage('https://research.pasteur.fr/wp-content/themes/biologyx2/images/map-pin.png', null, null, null, new google.maps.Size(32,32)); // create marker var marker = new google.maps.Marker({ position : latlng, map : map, icon : myIcon }); // add to array map.markers.push( marker ); // if marker contains HTML, add it to an infoWindow if( $marker.html() ) { // create info window var infowindow = new google.maps.InfoWindow({ content : $marker.html() }); // show info window when marker is clicked google.maps.event.addListener(marker, 'click', function() { infowindow.open( map, marker ); }); } } /* * center_map * * This function will center the map, showing all markers attached to this map * * @type function * @date 8/11/2013 * @since 4.3.0 * * @param map (Google Map object) * @return n/a */ function center_map( map ) { // vars var bounds = new google.maps.LatLngBounds(); // loop through all markers and create bounds $.each( map.markers, function( i, marker ){ var latlng = new google.maps.LatLng( marker.position.lat(), marker.position.lng() ); bounds.extend( latlng ); }); // only 1 marker? if( map.markers.length == 1 ) { // set center of map map.setCenter( bounds.getCenter() ); map.setZoom( 15 ); } else { // fit to bounds map.fitBounds( bounds ); } } /* * document ready * * This function will render each map when the document is ready (page has loaded) * * @type function * @date 8/11/2013 * @since 5.0.0 * * @param n/a * @return n/a */ $(document).ready(function(){ $('.acf-map').each(function(){ render_map( $(this) ); }); }); })(jQuery);