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© Research
Event

Department of Microbiology: «How bacteriophages protect themselves from CRISPR» by Joe Bondy Denomy

Scientific Fields
Diseases
Organisms
Applications
Technique
Date
26
Nov 2018
Time
11:00:00
25-28 Rue du Docteur Roux, Paris, France
Address
Building: Monod Room: Auditorium Jacques Monod
Location
2018-11-26 11:00:00 2018-11-26 12:00:00 Europe/Paris Department of Microbiology: «How bacteriophages protect themselves from CRISPR» by Joe Bondy Denomy Joe Bondy Denomy The University of California, San Fransisco «How bacteriophages protect themselves from CRISPR» Monday November 26th 2018 at 11:00 Auditorium Jacques Monod Bacterial CRISPR-Cas systems utilize sequence-specific RNA-guided nucleases to defend against […] 25-28 Rue du Docteur Roux, Paris, France Ivo Gomperts Boneca ivo.gomperts-boneca@pasteur.fr

About

Joe Bondy Denomy
The University of California, San Fransisco

«How bacteriophages protect themselves from CRISPR»

Monday November 26th 2018 at 11:00

Auditorium Jacques Monod

Bacterial CRISPR-Cas systems utilize sequence-specific RNA-guided nucleases to defend against bacteriophage (phage) infection. As a counter-measure, numerous phages produce proteins to block the function of the Class 1 CRISPR-Cas systems, which utilize multi-subunit protein complexes to enact immunity. Our group recently developed and utilized novel bioinformatics strategies to identify Class 2 (e.g. Cas9 and Cas12) anti-CRISPR proteins. We have identified anti-CRISPR proteins encoded by phages and mobile genetic elements from many organisms, including Pseudomonas aeruginosa, Listeria monocytogenes, Moraxella bovoculi, and Streptococcus pyogenes, suggesting widespread and common CRISPR-Cas inactivation. More recently, we have identified a phage with a novel mechanism of CRISPR evasion that does not rely on anti- CRISPR proteins, but instead physically segregates its genome from nucleases. I will discuss our progress towards understanding these variousmechanisms that phages deploy to avoid destruction by CRISPR-Cas. This work is multidisciplinary and unites fields spanning microbial/phage genetics, molecular biology, phage biology, structure, bioinformatics, gene editing, and cell biology

contact :
Ivo GOMPERTS BONECA (ivo.gomperts-boneca@pasteur.fr)

Location

Building: Monod
Room: Auditorium Jacques Monod
Address: 25-28 Rue du Docteur Roux, Paris, France