About

Abstact : The highly complex life cycle of the human malaria parasite, Plasmodium falciparum, relies on an orchestrated and tightly regulated gene expression programme. The access of regulatory factors to DNA is controlled by its packaging into nucleosomes, which limits DNA accessibility by binding to histone proteins. We are investigating the molecular mechanisms that determine DNA accessibility for regulatory factors, focusing on the role of chromatin remodelling complexes that are key regulators of gene expression. The talk will present new high-resolution insights into the parasite’s chromatin structure and the function of the essential chromatin remodelling enzyme PfSnf2L.
Website: www.laengstlab.com

