Neuronal circuits are constantly refined and remodeled in response to activity. Activity-induced plasticity is responsible for the brain’s ability to adjust to changing conditions, as in the sculpting of circuits during development, adaptation after injury, or incorporating new learning. Here, we used flow cytometry and RNA sequencing from single hippocampal neurons following behavioral stimulation to identify the molecular signature induced by neuronal activation and its consequence on future reactivation. Our results provide novel insights into how long-term activity-induced transcriptional changes are important for selecting the components of the original activated network that are ultimately involved in the encoding and retrieval of memories.
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