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© Research
Event

[C3BI Seminar]- Trey Ideker: Interpreting the cancer genome through physical and functional models of the cancer cell

Scientific Fields
Diseases
Organisms
Applications
Technique
Date
21
Jun 2019
Time
14:00:00
Institut Pasteur, Rue du Docteur Roux, Paris, France
Address
Building: Metchnikoff Room: Jules Bordet
Location
2019-06-21 14:00:00 2019-06-21 14:00:00 Europe/Paris [C3BI Seminar]- Trey Ideker: Interpreting the cancer genome through physical and functional models of the cancer cell Recently we and other laboratories have launched the Cancer Cell Map Initiative (ccmi.org) and have been building momentum. The goal of the CCMI is to produce a complete map of the gene and protein […] Institut Pasteur, Rue du Docteur Roux, Paris, France

About

Recently we and other laboratories have launched the Cancer Cell Map Initiative (ccmi.org) and have been building momentum. The goal of the CCMI is to produce a complete map of the gene and protein wiring diagram of a cancer cell. We and others believe this map, currently missing, will be a critical component of any future system to decode a patient’s cancer genome. I will describe efforts along several lines: 1. Coalition building. We have made notable progress in building a coalition of institutions to generate the data, as well as to develop the computational methodology required to build and use the maps. 2. Development of technology for mapping gene-gene interactions rapidly using the CRISPR system. 3. Causal network maps connecting DNA mutations (somatic and germline, coding and noncoding) to the cancer events they induce downstream. 4. Development of software and database technology to visualize and store cancer cell maps. 5. A machine learning system for integrating the above data to create multi-scale models of cancer cells. In a recent paper by Ma et al., we have shown how a hierarchical map of cell structure can be embedded with a deep neural network, so that the model is able to accurately simulate the effect of mutations in genotype on the cellular phenotype.

 

Location

Building: Metchnikoff
Room: Jules Bordet
Address: Institut Pasteur, Rue du Docteur Roux, Paris, France