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  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Department Manager
  • Full Professor
  • Graduate Student
  • Honorary Professor
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
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About

Université Paris-Saclay, CEA, CNRS, laboratory of Neurodegenerative diseases: Mechanisms, Therapies, Imaging – Commissariat à l’énergie atomique et aux énergies alternatives, MIRCen, 18 route du panorama, Fontenay-aux-Roses, France .
Our team focuses on the use of human pluripotent stem cell (hPSC) derivatives as a key biological resource for basic and translational research on neurological diseases. Our main objectives are 1) to investigate the molecular basis of brain cells regional vulnerability in Huntington’s disease and Synucleinopathies exploring in particular dysfunctional neuron-glia interactions during neurodegeneration, 2) to develop and use innovative cellular disease models based on hPSCs for drug discovery or drug validation and 3) to develop methods to optimize the efficacy of cell therapy for Huntington’s disease using hPSC-derived grafts.