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Director of Center
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Pluripotent stem cells in mammals (SBRI, Inserm)

Biology of the neuromuscular system (IMRB, Inserm, Créteil)

© Research

Partner Team

ALS : causes and mechanisms of motor neuron degeneration (ICM)

Severine Boillee (ICM)

Head

Delphine Bohl (ICM, Paris)

Head

Institut du cerveau et la moelle

Scientific Fields

Diseases

Organisms

Applications

Technique

Scientific Fields

Cell biology and developmental
Public health research and cli

About

Main domain : Cellular & molecular neurosciences Subdomain : Clinical & translational neurosciences Séverine BOILLEE’s team investigates mechanisms of motor neuron (MN) degeneration in Amyotrophic Lateral Sclerosis (ALS or Lou Gehrig’s disease) resulting from pathological interactions between MNs and microglia/macrophages to find therapeutically promising pathways to slow disease progression through two main aims:

To understand how known/new ALS genes, identified using dedicated genetic approaches, lead to MN death and deregulated microglial responses
Focusing on the unique characteristics of spinal MNs, to assess impact and ALS disease modifying capacities of peripheral nerve macrophages (vs CNS microglia)

Transversal Project

LabEx Revive – Regenerative biology & medicine

Rationale and Objectives of Revive Consortium Major advancements in stem cell biology have paved the way for concerted research activities on the fundamental biology of stem cells and their applications in the clinic. The […]

Institution

Published on: 20 Jan 2023