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© Research
Publication : Journal of structural biology

Efficient automatic noise reduction of electron tomographic reconstructions based on iterative median filtering.

Member: Niels Volkmann
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of structural biology - 01 May 2007

van der Heide P, Xu XP, Marsh BJ, Hanein D, Volkmann N,

Link to Pubmed [PMID] – 17224280

J Struct Biol 2007 May; 158(2): 196-204

A simple, fast and efficient noise-reduction protocol for three-dimensional electron tomographic reconstructions of biological material is presented. The approach is based on iterative application of median filtering and shows promise for automatic noise reduction as a pre-processor for automated data analysis tools which aim at segmentation, feature extraction and pattern recognition. The application of this algorithm produces encouraging results for a wide variety of experimental and synthetic electron tomographic reconstructions.