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© Research
Publication : Organic & Biomolecular Chemistry

Gold-Catalyzed Enantioselective Functionalizations of Indoles

Team: Bioorganic chemistry of nucleic acids
Team: UMR3523 – Chemistry for Life Sciences (Chem4Life)
Member: Nazarii Sabat
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Organic & Biomolecular Chemistry - 14 Jul 2020

Milcendeau, P.; Sabat, N.; Ferry, A.; Guinchard, X.

Link to DOI – 10.1039/D0OB01245A

Org. Biomol. Chem. 2020, 18, 6006 – 6017

Gold catalysis and indole chemistry are two mature and prolific fields. The gold-catalyzed functionalization of indoles has produced numerous results and paved the way for novel strategies in the building of molecular complexity. However – and curiously – though enantioselective gold catalysis is now a well-established field, it has been relatively little applied to the modification of indoles. This review highlights most of the enantioselective gold-catalyzed examples of the functionalization of indoles in order to emphasize the strengths and limitations of the method.