“New drugs for African trypanosomiasis from control to elimination ?” Pascal MAESER | Research - Institut Pasteur

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Cancelled (will be postponed) – Global Health Department Seminar “Molecular insights into host-pathogen reveals potential new therapeutic targets for MRSA and streptococci”

Rosetting of Plasmodium-infected red blood cells: severity factor or escape mechanism ? – Laurent RENIA

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20

Jun 2019

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12:00:00

Institut Pasteur, Rue du Docteur Roux, Paris, France

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Building: Lwoff

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2019-06-20 12:00:00 2019-06-20 14:00:00 Europe/Paris “New drugs for African trypanosomiasis from control to elimination ?” Pascal MAESER Pascal MAESER – Head of Parasite Chemotherapy – Swiss Tropical and Public Health Institute Human African trypanosomiasis (HAT) is caused by Trypanosoma brucei rhodesiense in East Africa, and by T. b. gambiense in West […] Institut Pasteur, Rue du Docteur Roux, Paris, France Philippe Bastin philippe.bastin@pasteur.fr

About

Pascal MAESER – Head of Parasite Chemotherapy – Swiss Tropical and Public Health Institute

Human African trypanosomiasis (HAT) is caused by Trypanosoma brucei rhodesiense in East Africa, and by T. b. gambiense in West and Central Africa. The vectors (and definite hosts) for all T. brucei subspecies are the tsetse flies, Glossina spp. The incidence of HAT being at a historic low, the elimination of the disease as a public health problem may finally be tangible – but only with a new, safe and uncomplicated treatment option. There is no shortage of potential drug targets. The African trypanosomes possess numerous biochemical peculiarities that are essential to the parasites but absent in mammalian cells, i.e. trypanothione metabolism, the kinetoplast, the glycosomes and RNA editing. However, target-based approaches have so far not yielded novel drug candidates. The molecules that have progressed to the clinical phases of development (pafuramidine, fexinidazole, and the benzoxaborole SCYX-7158) had been discovered in cell-based screens. I shall compare different strategies for drug discovery against HAT and recapitulate the success story of fexinidazole, which in November 2018 has received positive opinion from the European Medicines Agency as the first oral treatment for HAT.

Link to your website: https://www.swisstph.ch/de/ueber-uns/mpi/parasite-chemotherapy/

Location

Building: Lwoff
Address: Institut Pasteur, Rue du Docteur Roux, Paris, France

Published on: 14 May 2019 • Modified on: 18 Jun 2019

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