Carolina Parada earned her PhD at the University of Barcelona and completed postdoctoral research at the University of Southern California before joining Jérôme Gros’s group in 2016. She obtained a permanent researcher position in 2023 and has studied diverse aspects of organogenesis throughout her career. At Institut Pasteur, she has worked on digit cartilage formation, with focus on the interplay between signaling and tissue mechanics. She continues exploring how dynamic cell behaviors and mechanical cues guide tissue shaping and its connection to cell fate decisions during mouse limb development. She is particularly interested in the emergence of periodic patterns that underlie the complex anatomy of the hand skeleton.
Publications
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2022Mechanical feedback defines organizing centers to drive digit emergence., Dev Cell 2022 Apr; 57(7): 854-866.e6.
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2017The Dlx5-FGF10 signaling cascade controls cranial neural crest and myoblast interaction during oropharyngeal patterning and development., Development 2017 Nov; 144(21): 4037-4045.
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2015Disruption of the ERK/MAPK pathway in neural crest cells as a potential cause of Pierre Robin sequence., Development 2015 Nov; 142(21): 3734-45.
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2015A Comprehensive Study of Soft Palate Development in Mice., PLoS One 2015 ; 10(12): e0145018.
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2013CTGF mediates Smad-dependent transforming growth factor β signaling to regulate mesenchymal cell proliferation during palate development., Mol Cell Biol 2013 Sep; 33(17): 3482-93.
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2012Molecular and cellular regulatory mechanisms of tongue myogenesis., J Dent Res 2012 Jun; 91(6): 528-35.
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2012A TGFβ-Smad4-Fgf6 signaling cascade controls myogenic differentiation and myoblast fusion during tongue development., Development 2012 May; 139(9): 1640-50.
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2012Fibroblast growth factor 9 (FGF9)-pituitary homeobox 2 (PITX2) pathway mediates transforming growth factor β (TGFβ) signaling to regulate cell proliferation in palatal mesenchyme during mouse palatogenesis., J Biol Chem 2012 Jan; 287(4): 2353-63.
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2011Jagged 1 regulates the restriction of Sox2 expression in the developing chicken inner ear: a mechanism for sensory organ specification., Development 2011 Feb; 138(4): 735-44.