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© Institut Pasteur
Phlébotome. Petit diptère de la famille des psychodidés (dans l'Ancien Monde). La femelle hématophage peut être vectrice entre autres de leishmaniose qu'elle transmet par piqûre à un vertébré, chien (hôte principal réservoir), homme ou encore rat (hôtes occasionnels).
Publication : Advances in virus research

Antiviral Immune Response and the Route of Infection in Drosophila melanogaster

Team: Viruses and RNA Interference
Member: Carla Saleh
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Advances in virus research - 21 Nov 2017

Mondotte JA, Saleh MC

Link to Pubmed [PMID] – 29551139

Adv. Virus Res. 2018;100:247-278

The use of Drosophila as a model organism has made an important contribution to our understanding of the function and regulation of innate immunity in insects. Indeed, insects can discriminate between different types of pathogens and mount specific and effective responses. Strikingly, the same pathogen can trigger a different immune response in the same organism, depending solely on the route of infection by which the pathogen is delivered. In this review, we recapitulate what is known about antiviral responses in Drosophila, and how they are triggered depending on the route and the mode used for the virus to infect its host.