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© Research
Publication : Journal of fungi (Basel, Switzerland)

Understanding Pathogenesis and Care Challenges of Immune Reconstitution Inflammatory Syndrome in Fungal Infections

Reference Center: Invasive Mycoses and Antifungals
Member: Fanny Lanternier
Member: Olivier Lortholary
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of fungi (Basel, Switzerland) - 17 Dec 2018

Dellière S, Guery R, Candon S, Rammaert B, Aguilar C, Lanternier F, Chatenoud L, Lortholary O

Link to Pubmed [PMID] – 30562960

J Fungi (Basel) 2018 Dec;4(4)

Immune deficiency of diverse etiology, including human immunodeficiency virus (HIV), antineoplastic agents, immunosuppressive agents used in solid organ recipients, immunomodulatory therapy, and other biologics, all promote invasive fungal infections. Subsequent voluntary or unintended immune recovery may induce an exaggerated inflammatory response defining immune reconstitution inflammatory syndrome (IRIS), which causes significant mortality and morbidity. Fungal-associated IRIS raises several diagnostic and management issues. Mostly studied with , it has also been described with other major fungi implicated in human invasive fungal infections, such as , , , and . Furthermore, the understanding of IRIS pathogenesis remains in its infancy. This review summarizes current knowledge regarding the clinical characteristics of IRIS depending on fungal species and existing strategies to predict, prevent, and treat IRIS in this patient population, and tries to propose a common immunological background to fungal IRIS.