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© Therese Couderc, Marc Lecuit
Publication : Annales de dermatologie et de venereologie

[The role of reflectance confocal microscopy in the diagnosis of secondary syphilis of the vulva and anus: A first case report]

Team: Biology of infection
Member: Alexandre Leclercq
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Annales de dermatologie et de venereologie - 25 Aug 2016

Leclercq A, Cinotti E, Labeille B, Cribier B, Biron AC, Vermersch C, Montlouis J, Cambazard F, Perrot JL,

Link to Pubmed [PMID] – 27567281

Ann Dermatol Venereol 2016 Nov;143(11):687-690

PATIENTS AND METHODS: Herein we report the case of an 18-year-old pregnant patient presenting with plantar and ano-genital lesions of syphilis, pharyngitis, erythematosus and scalynasolabial intertrigo and angular cheilitis.

REFLECTANCE CONFOCAL MICROSCOPY: In vivo reflectance confocal microscopy examination (Vivascope 3000; Caliber Inc, Rochester, NY, USA, distributed in France by Mavig, Munich) of ano-genital lesions enabled us to identify hyper-reflective elongated rods in the papillary dermis suggesting spirochetes. The diagnosis was confirmed by TPHA and VDRL as well as immunohistological examination.

COMMENTS: We identified for the first time rod shaped structures in ano-genital lesions of secondary syphilis, regularly alternating hyper-reflective and non-reflective areas corresponding to helix-shaped treponemes visualized by darkfield microscopy, which may not be confused with other cell structures.