New total synthesis and high resolution 1H NMR spectrum of platelet-activating factor, its enantiomer and racemic mixtures | Research - Institut Pasteur

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Synthesis and biological activity of some structural analogs of platelet-activating factor (PAF-acether)

There are approximately 20 actin gene in the human genome.

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Diseases

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Published in Biochimica et biophysica acta - 23 Nov 1981

Heymans F, Michel E, Borrel MC, Wichrowski B, Godfroid JJ, Convert O, Coeffier E, Tence M, Benveniste J

Link to Pubmed [PMID] – 7306563

Biochim. Biophys. Acta 1981 Nov;666(2):230-7

A new method of synthesis of octadecyl platelet-activating factor (PAF; 1-O-octadecyl 2-O-acetyl sn-glycero-3-phosphorylcholine) is described. Its advantage is to proceed by way of the ‘lyso-PAF’ which may be substituted by various groups, while avoiding the inconveniences of the total synthesis already described. Moreover, the intermediates in synthesis are easier to purify, with better yields. The platelet-aggregating activity of synthetic PAF, is enantiomer (3-O-octadecyl) and racemic mixtures were 2.7 . 10(-10), 1.7 . 10(-7) and 2.2 . 10(-10) M, respectively. These results indicate the stereospecificity of platelet activation induced by PAF.

Published on: 23 Nov 1981