In this PhD project we want to better understand DNA modifications, especially DNA methylation in Plasmodium falciparum genome and the role of these modifications in the regulation of Var gene expression.
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Timeline
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Publications
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2023Plasmodium falciparum Eukaryotic Translation Initiation Factor 3 is Stabilized by Quinazoline-Quinoline Bisubstrate Inhibitors., ACS Infect Dis 2023 May; (): .
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2021Malaria Parasite Stress Tolerance Is Regulated by DNMT2-Mediated tRNA Cytosine Methylation, mBio. 2021 Nov-Dec; 12(6): e02558-21.
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2021Procainamide-SAHA Fused Inhibitors of hHDAC6 Tackle Multidrug-Resistant Malaria Parasites., J Med Chem 2021 07; 64(14): 10403-10417.