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© Research
Publication : Infection and immunity

Characterization of adenylate cyclase-hemolysin gene duplication in a Bordetella pertussis isolate

Reference Center: Whooping Cough and other Bordetella infections
Member: Nicole Guiso
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Infection and immunity - 01 Aug 2004

Dalet K, Weber C, Guillemot L, Njamkepo E, Guiso N

Link to Pubmed [PMID] – 15271951

Infect. Immun. 2004 Aug;72(8):4874-7

We describe a clinical isolate of Bordetella pertussis, the agent responsible for whooping cough, composed of at least two clones harboring one or two copies of the cya locus encoding one of the major toxins, adenylate cyclase-hemolysin. No difference was observed between the two clones in murine and cellular models, probably due to the high instability of the cya locus duplication.