Sustained exacerbation of cryoglobulinaemia-related vasculitis following treatment of hepatitis C with peginterferon alfa | Research - Institut Pasteur

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Phylogenetic characteristics of three new HIV-1 N strains and implications for the origin of group N.

Over-expression of Rififylin, a new RING finger and FYVE-like domain-containing protein, inhibits recycling from the endocytic recycling compartment

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Published in European journal of gastroenterology & hepatology - 01 Jul 2004

Batisse D, Karmochkine M, Jacquot C, Kazatchkine MD, Weiss L

Link to Pubmed [PMID] – 15201585

Eur J Gastroenterol Hepatol 2004 Jul;16(7):701-3

Peginterferon is now the gold standard of therapy in patients with chronic hepatitis C virus infection. Extrahepatic manifestations of HCV are usually treated with interferon alfa. Here we report on a patient with HCV-related cirrhosis and cryoglobulinaemia who presented with an acute and long-lasting exacerbation of vasculitis during treatment with peginterferon. To our knowledge this is the first report of an acute exacerbation of cryoglobulinaemia-related vasculitis involving skin, peripheral nerve and kidney in a patient treated with peginterferon for HCV-related cirrhosis. The long half-life of peginterferon might explain the long-lasting symptoms of vasculitis. Clinicians should be aware of possible sustained flare of cryoglobulinaemia-associated vasculitis in patients receiving peginterferon.

Published on: 01 Jul 2004