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© Research
Publication : European journal of cancer (Oxford, England : 1990)

Interleukin-2 and interleukin-4 display potent antitumour activity on rat medullary thyroid carcinoma cells

Team: Ecology and Emergence of Arthropod-borne Pathogens
Member: Claude Roth
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in European journal of cancer (Oxford, England : 1990) - 01 Dec 1995

Cressent M, Pidoux E, Cohen R, Modigliani E, Roth C

Link to Pubmed [PMID] – 8652272

Eur. J. Cancer 1995 Dec;31A(13-14):2379-84

Currently, surgical resection is the only treatment used for human medullary thyroid carcinoma (MTC). However, as metastases are commonly observed, we investigated the potential of adjuvant therapy with interleukin-2 (IL-2) and interleukin-4 (IL-4) in a rat model. The interleukins were delivered by means of xenogeneic tumour cells engineered to secrete IL-2 and IL-4. We found that when a mixture of MTC cells and IL-2 or IL-4 secreting cells were implanted in rats, the growth of the resulting tumours was inhibited as a function of the number of interleukin-secreting cells in the inoculum. Moreover, association of the two interleukins exerted a synergistic antitumour effect. These experimental results, showing thyroid C cell tumour rejection, are of major interest, as they show the potential therapeutic application for these two interleukins, which could be used, in particular, as postsurgical adjuvants.