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© Thierry Blisnick & Philippe Bastin, Institut Pasteur
Bloodstream Trypanosoma brucei cell
Publication : Research in microbiology

Genetic interference in protozoa

Team: Trypanosome Cell Biology
Member: Philippe Bastin
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Research in microbiology - 01 Mar 2001

Bastin P, Galvani A, Sperling L

Link to Pubmed [PMID] – 11316365

Res. Microbiol. 2001 Mar;152(2):123-9

RNA interference first described in Caenorhabditis elegans and transgene-induced post-transcriptional gene silencing first described in plants and fungi now appear as different means of activating a conserved and ancient mechanism that can protect genomes against viruses and transposons and perhaps also control expression of endogenous genes. We present here similar genetic interference phenomena in highly divergent protozoa, Trypanosoma and Paramecium, and look ahead to what contribution these microorganisms could bring to this fast-moving area.