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© Thierry Blisnick & Philippe Bastin, Institut Pasteur
Bloodstream Trypanosoma brucei cell
Publication : Science (New York, N.Y.)

Molecular basis of tubulin transport within the cilium by IFT74 and IFT81

Team: Trypanosome Cell Biology
Member: Philippe Bastin
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Science (New York, N.Y.) - 30 Aug 2013

Bhogaraju S, Cajanek L, Fort C, Blisnick T, Weber K, Taschner M, Mizuno N, Lamla S, Bastin P, Nigg EA, Lorentzen E

Link to Pubmed [PMID] – 23990561

Science 2013 Aug;341(6149):1009-12

Intraflagellar transport (IFT) of ciliary precursors such as tubulin from the cytoplasm to the ciliary tip is involved in the construction of the cilium, a hairlike organelle found on most eukaryotic cells. However, the molecular mechanisms of IFT are poorly understood. Here, we found that the two core IFT proteins IFT74 and IFT81 form a tubulin-binding module and mapped the interaction to a calponin homology domain of IFT81 and a highly basic domain in IFT74. Knockdown of IFT81 and rescue experiments with point mutants showed that tubulin binding by IFT81 was required for ciliogenesis in human cells.