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© Research
Publication : Journal of Heterocyclic Chemistry

A simple two steps ytterbium triflate-catalysed preparation of 2,2-dimethylchromenes from salicylaldehydes and 2-methylpropene

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of Heterocyclic Chemistry - 01 Jan 2006

Prado, S.; Janin, Y. L.; Bost, P. E.

J. Heterocycl. Chem. 2006, 43, 1605-1608

The preparation of various 2,2-dimethyl-2H-chromenes was achieved in two steps via an ytterbium triflate-catalysed reaction between salicylaldehydes, trimethylorthoformate and 2-methylpropene. From salicylaldehyde, two reaction products were characterised: 4-methoxy-2,2-dimethylchroman and 2-(1,3-dimethoxy-3-methylbutyl)phenol. The former compound probably results from a Lewis acid-catalysed [2+4] cycloaddition between the intermediate quinonemethide and 2-methylpropene whereas the latter may occur via a reaction related to a carbonyl-ene reaction between the quinonemethide and 2-methylpropene. Both compounds were subjected to a catalytic acidic treatment leading to 2,2-dimethyl-2H-chromene. Starting from various salicylaldehydes, the scope of this method was investigated