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  • project
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  • tool
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  • Assistant Professor
  • Associate Professor
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  • Clinical Research Nurse
  • Clinician Researcher
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  • Master Student
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  • Nursing Staff
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
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  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
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© Research
Publication : Trends in immunology

From induced to programmed lymphoid tissues: the long road to preempt pathogens

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Trends in immunology - 07 Sep 2007

Eberl G

Link to Pubmed [PMID] – 17826332

Trends Immunol. 2007 Oct;28(10):423-8

In mammalian fetuses, ontogeny dictates the development of secondary lymphoid tissues, the spleen, the lymph nodes and the Peyer’s patches. In adults, commensals, infectious microbes and inflammation induce the formation of small reversible lymphoid tissues resembling lymph nodes or Peyer’s patches. Crucial to lymphoid-tissue genesis is lymphotoxin-beta receptor-mediated activation of inflammatory effectors and structural chemokines. This pathway might have existed since the advent of the vertebrate lymphocyte system to organize local adaptive immunity in response to microbes; however, it only operates in the absence of microbes in mammals, resulting in the development of secondary lymphoid tissues and in preempting pathogens.