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© Research
Publication : Malaria journal

A major genetic locus controlling natural Plasmodium falciparum infection is shared by East and West African Anopheles gambiae

Team: Insect-Virus Interactions
Member: Louis Lambrechts
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Malaria journal - 06 Jul 2007

Riehle MM, Markianos K, Lambrechts L, Xia A, Sharakhov I, Koella JC, Vernick KD

Link to Pubmed [PMID] – 17612409

Malar. J. 2007;6:87

Genetic linkage mapping identified a region of chromosome 2L in the Anopheles gambiae genome that exerts major control over natural infection by Plasmodium falciparum. This 2L Plasmodium-resistance interval was mapped in mosquitoes from a natural population in Mali, West Africa, and controls the numbers of P. falciparum oocysts that develop on the vector midgut. An important question is whether genetic variation with respect to Plasmodium-resistance exists across Africa, and if so whether the same or multiple geographically distinct resistance mechanisms are responsible for the trait.