The hydrophobic domain of the Mycobacterial Erp protein is not essential for the virulence of Mycobacterium tuberculosis | Research - Institut Pasteur

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Published in Infection and immunity - 01 Apr 2004

Kocíncová D, Sondén B, Bordat Y, Pivert E, de Mendonça-Lima L, Gicquel B, Reyrat JM

Link to Pubmed [PMID] – 15039363

Infect. Immun. 2004 Apr;72(4):2379-82

Erp (exported repetitive protein) is a member of a mycobacterium-specific family of extracellular proteins. A hydrophobic region that is localized at the C-terminal domain and that represents a quarter of the protein is highly conserved across species. Here we show that this hydrophobic region is not essential for restoring the virulence and tissue damage of an erp::aph mutant strain of M. tuberculosis as assessed by bacterial counts and lung histology analysis in a mouse model of tuberculosis.

Published on: 01 Apr 2004