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© Research
Publication : BMC developmental biology

Regionalization of the mouse visceral endoderm as the blastocyst transforms into the egg cylinder

Team: Heart Morphogenesis
Member: Sigolène Meilhac
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in BMC developmental biology - 16 Aug 2007

Perea-Gomez A, Meilhac SM, Piotrowska-Nitsche K, Gray D, Collignon J, Zernicka-Goetz M

Link to Pubmed [PMID] – 17705827

BMC Dev. Biol. 2007;7:96

Reciprocal interactions between two extra-embryonic tissues, the extra-embryonic ectoderm and the visceral endoderm, and the pluripotent epiblast, are required for the establishment of anterior-posterior polarity in the mouse. After implantation, two visceral endoderm cell types can be distinguished, in the embryonic and extra-embryonic regions of the egg cylinder. In the embryonic region, the specification of the anterior visceral endoderm (AVE) is central to the process of anterior-posterior patterning. Despite recent advances in our understanding of the molecular interactions underlying the differentiation of the visceral endoderm, little is known about how cells colonise the three regions of the tissue.