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© Cédric Delevoye
Cellules infectÈes par Chlamydia trachomatis. Les bactÈries se dÈveloppent dans une vacuole (rouge), ‡ proximitÈ du noyau de la cellule-hÙte (bleu). Ce compartiment interagit de faÁon Ètroite avec ceux de la cellule hÙte. Marquage vert= localisation d'une protÈine de l'hÙte, Vamp8, exprimÈe par transfection. Les Chlamydia sont, selon les souches, responsables de maladies sexuellement transmises, de cÈcitÈs, d'infections pulmonaires et pourraient Ítre impliquÈes dans l'athÈrosclÈrose.
Publication : BMC microbiology

Small molecule inhibitors of the Yersinia type III secretion system impair the development of Chlamydia after entry into host cells

Team: Cellular Biology of Microbial Infection
Member: Agathe Subtil
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in BMC microbiology - 21 Apr 2009

Muschiol S, Normark S, Henriques-Normark B, Subtil A

Link to Pubmed [PMID] – 19383140

BMC Microbiol. 2009;9:75

Chlamydiae are obligate intracellular pathogens that possess a type III secretion system to deliver proteins into the host cell during infection. Small molecule inhibitors of type III secretion in Yersinia, termed INPs (Innate Pharmaceuticals AB) were reported to strongly inhibit Chlamydia growth in epithelial cells. In this study we have analyzed the effect of these drugs on bacterial invasiveness.