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Dendritic varicosities as novel microtubule organisingcentres in Drosophila neuron

SaMMBA seminar: Roger Kouyos (Univ Hospital Zurich)

© Muriel Delepierre, Institut Pasteur

Event

EPI-PROTEOMICS TO DECODE CHROMATIN AND PROTEIN METHYLATION REWIRING IN CANCER THERAPY RESISTANCE

Team: UMR3523 – Chemistry for Life Sciences (Chem4Life)

Department of: Structural Biology and Chemistry

Member: Paola Arimondo

Member: Blanca Rojo Guyon

Scientific Fields

Diseases

Organisms

Applications

Technique

Date

10

Mar 2026

Time

11:00:00

Institut Pasteur, Rue du Docteur Roux, Paris, France

Address

Room: Auditorium Agnès Ullmann

Location

2026-03-10 11:00:00 2026-03-10 12:00:00 Europe/Paris EPI-PROTEOMICS TO DECODE CHROMATIN AND PROTEIN METHYLATION REWIRING IN CANCER THERAPY RESISTANCE Tiziana BONALDI Department of Experimental Oncology, European Institute of Oncology (IEO), Milano -Italy) External attendees wishing to participate in the seminar are required to contact the following email address dbsc@pasteur.fr in order to obtain access to […] Institut Pasteur, Rue du Docteur Roux, Paris, France Paola Arimondo paola.arimondo@pasteur.fr

About

Tiziana BONALDI

Department of Experimental Oncology, European Institute of Oncology (IEO), Milano -Italy)

External attendees wishing to participate in the seminar are required to contact the following email address dbsc@pasteur.fr in order to obtain access to the Institut Pasteur premises at least one week before the event.

Abstract

Resistance to cancer therapy is often driven by adaptive epigenetic and proteomic rewiring rather than fixed genetic alterations. In this seminar, I will present how epi-proteomics approaches can be used to systematically dissect changes in chromatin states and protein methylation programs that sustain tumor cell survival under therapeutic pressure.

Using mass spectrometry–based profiling of histone and non-histone methylation of clinical and pre-clinical samples, combined with functional perturbation, we have characterized cancer-specific methylation landscapes in triple-negative breast cancer (TNBC)and high-grade ovarian cancer. In TNBC, analysis of patient-derived material revealed sustained H3K4me3-associated transcriptional programs supporting aggressive tumor phenotypes. In ovarian cancer, ongoing work identifies alterations in H3K27me3 linked to platinum resistance, highlighting epigenetic plasticity as a key determinant of chemoresistant states

Finally, I will briefly introduce methyl-proteomics strategies to explore non-histone methylation as an additional regulatory layer in cancer therapy resistance.

Location

Room: Auditorium Agnès Ullmann
Address: Institut Pasteur, Rue du Docteur Roux, Paris, France

Published on: 03 Feb 2026

(function($) { /* * render_map * * This function will render a Google Map onto the selected jQuery element * * @type function * @date 8/11/2013 * @since 4.3.0 * * @param $el (jQuery element) * @return n/a */ function render_map( $el ) { var MY_MAPTYPE_ID = 'custom_style'; var featureOpts = [{"stylers":[{"hue":"#0088ff"}]}]; var styledMapOptions = { name: 'Custom Style' }; var customMapType = new google.maps.StyledMapType(featureOpts, styledMapOptions); // var var $markers = $el.find('.marker'); // vars var args = { zoom : 16, scrollwheel : false, center : new google.maps.LatLng(0, 0), mapTypeId : google.maps.MapTypeId.ROADMAP, mapTypeId : MY_MAPTYPE_ID }; // create map var map = new google.maps.Map( $el[0], args); map.mapTypes.set(MY_MAPTYPE_ID, customMapType); // add a markers reference map.markers = []; // add markers $markers.each(function(){ add_marker( $(this), map ); }); // center map center_map( map ); } /* * add_marker * * This function will add a marker to the selected Google Map * * @type function * @date 8/11/2013 * @since 4.3.0 * * @param $marker (jQuery element) * @param map (Google Map object) * @return n/a */ function add_marker( $marker, map ) { // var var latlng = new google.maps.LatLng( $marker.attr('data-lat'), $marker.attr('data-lng') ); //var image = 'https://research.pasteur.fr/wp-content/themes/biologyx2/images/logomap.png'; var myIcon = new google.maps.MarkerImage('https://research.pasteur.fr/wp-content/themes/biologyx2/images/map-pin.png', null, null, null, new google.maps.Size(32,32)); // create marker var marker = new google.maps.Marker({ position : latlng, map : map, icon : myIcon }); // add to array map.markers.push( marker ); // if marker contains HTML, add it to an infoWindow if( $marker.html() ) { // create info window var infowindow = new google.maps.InfoWindow({ content : $marker.html() }); // show info window when marker is clicked google.maps.event.addListener(marker, 'click', function() { infowindow.open( map, marker ); }); } } /* * center_map * * This function will center the map, showing all markers attached to this map * * @type function * @date 8/11/2013 * @since 4.3.0 * * @param map (Google Map object) * @return n/a */ function center_map( map ) { // vars var bounds = new google.maps.LatLngBounds(); // loop through all markers and create bounds $.each( map.markers, function( i, marker ){ var latlng = new google.maps.LatLng( marker.position.lat(), marker.position.lng() ); bounds.extend( latlng ); }); // only 1 marker? if( map.markers.length == 1 ) { // set center of map map.setCenter( bounds.getCenter() ); map.setZoom( 15 ); } else { // fit to bounds map.fitBounds( bounds ); } } /* * document ready * * This function will render each map when the document is ready (page has loaded) * * @type function * @date 8/11/2013 * @since 5.0.0 * * @param n/a * @return n/a */ $(document).ready(function(){ $('.acf-map').each(function(){ render_map( $(this) ); }); }); })(jQuery);