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© Research
Publication : Virus research

Genome analysis of dengue type-1 virus isolated between 1990 and 2001 in Brazil reveals a remarkable conservation of the structural proteins but amino acid differences in the non-structural proteins.

Team: UMR3569 – Virology
Team: Structural Virology
Member: Félix A. Rey
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Virus research - 01 Dec 2002

dos Santos CN, Rocha CF, Cordeiro M, Fragoso SP, Rey F, Deubel V, Desprès P

Link to Pubmed [PMID] – 12457974

Virus Res 2002 Dec; 90(1-2): 197-205

We have investigated the genetic diversity of dengue type-1 (DEN-1) virus in Brazil. The full nucleotide sequences of three DEN-1 virus isolated from DEN fever (DF) and DEN hemorrhagic fever patients in northeastern Brazil in 1997 (BR/97) and one from a DF patient in the south of Brazil in 2001 (BR/01) were compared to that of the reference strain BR/90 obtained in the city of Rio de Janeiro in 1990. Sequence analysis showed that the structural proteins were remarkably conserved between all isolates. A total of 27 amino acid changes occurred throughout the non-structural proteins. Among them, nine amino acid substitutions were specific of BR/97 and BR/01 isolates, indicating that in situ evolution of these strains had occurred. Within the BR/97 and BR/01 samples, some amino acid substitutions have been previously identified in DEN-1 virus strains sequenced so far, suggesting that recombination events might have occurred.