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© Christine Schmitt, Anubis Vega Rua, Jean-Marc Panaud
Tête de moustique femelle Aedes albopictus, vecteur du virus de la dengue et du chikungunya. Microphotographie électronique à balayage, image colorisée.
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Medecine sciences : M/S - 01 Mar 2025

Brézillon-Dubus L, Dupuis B, Failloux AB

Link to Pubmed [PMID] – 40117551

Link to DOI – 10.1051/medsci/2025025

Med Sci (Paris) 2025 Mar; 41(3): 260-272

Dengue fever is a viral disease transmitted by mosquitoes of the Aedes genus, whose incidence and range have been steadily increasing in recent decades. Causing hemorrhagic fever in severe cases, it affects the inter-tropical regions of the world and threatens to spread to new geographical areas. Its complex pathophysiology and the existence of four genetically distant serotypes make vaccine development a challenge. Currently, there is no specific treatment against dengue fever and only a few vaccines are marketed or in development, with some limitations on their use. It is therefore necessary to develop new vaccines and identify new molecules with antiviral properties to reduce the economic and public health burden of this disease in endemic areas.Traitements et vaccins contre la dengue.La dengue est une maladie virale transmise par les moustiques du genre Aedes, dont l’incidence et l’aire de répartition sont en constante augmentation depuis les dernières décennies. Causant des fièvres hémorragiques dans les cas graves, elle touche principalement les zones tropicales et subtropicales du globe, et menace de s’étendre à de nouvelles zones géographiques. Il n’existe actuellement aucun traitement spécifique contre la dengue et, du fait de sa physiopathologie complexe et de l’existence de quatre sérotypes viraux distincts mais étroitement apparentés, c’est une maladie pour laquelle l’élaboration d’un vaccin est un vrai défi. Seuls quelques vaccins sont actuellement commercialisés ou en cours de développement. Cependant, leur utilisation est soumise à certaines restrictions. Il est donc nécessaire de poursuivre la recherche sur de nouveaux vaccins et d’identifier de nouvelles molécules à activités antivirales pour alléger le fardeau de santé publique et économique que représente cette maladie dans les zones d’endémie.