Timeline

Jack Christophe Cossec
Permanent Researcher
07 Jan 2026
team

Dynamics of Biological Identities

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26 Sep 2025
publication

Culture of pluripotent stem cells in microscale droplets modulates differentiation and tissue patterning towards organoids on chip.

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19 Jul 2025
publication

SUMO operates from a unique long tandem repeat to keep innate immunity in check.

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01 Jun 2025
publication

Transient pharmacological inhibition of SUMOylation during pregnancy induces craniofacial malformations in offspring mice.

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17 Sep 2023
publication

Generation of embryo-like structures from mouse embryonic stem cells treated with a chemical inhibitor of SUMOylation and cultured in microdroplets.

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26 May 2023
news

New publication – Transient suppression of SUMOylation in embryonic stem cells generates embryo like structures

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15 Apr 2023
publication

Transient suppression of SUMOylation in embryonic stem cells generates embryo-like structures.

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06 Oct 2021
project

Integrating the activities of SUMO in gene expression, inflammation and cancer (ERC-2011-AdG SUMOSTRESS)

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06 Oct 2021
project

Chromatin role of SUMO in oncogenesis

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06 Oct 2020
publication

Extensive SUMO Modification of Repressive Chromatin Factors Distinguishes Pluripotent from Somatic Cells.

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15 Sep 2020
publication

Extensive SUMO Modification of Repressive Chromatin Factors Distinguishes Pluripotent from Somatic Cells.

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24 Jun 2020
publication

Ultrastructural and dynamic studies of the endosomal compartment in Down syndrome.

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18 Jul 2019
project

Deconstructing the role of SUMO on chromatin in cell identity and tissue repair (ERC-2018-AdG SUMiDENTITY)

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01 Nov 2018
publication

SUMO Safeguards Somatic and Pluripotent Cell Identities by Enforcing Distinct Chromatin States.

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22 Oct 2018
publication

SUMO safeguards somatic and pluripotent cell identities by enforcing distinct chromatin states

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19 Jul 2018
course

Morning session – Introduction to NGS data analysis

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14 Dec 2015
publication

Sumoylation coordinates the repression of inflammatory and anti-viral gene-expression programs during innate sensing.

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07 Jul 2015
publication

Modifications of the endosomal compartment in peripheral blood mononuclear cells and fibroblasts from Alzheimer’s disease patients.

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26 Jul 2013
publication

Sumoylation at chromatin governs coordinated repression of a transcriptional program essential for cell growth and proliferation.

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17 Apr 2012
publication

Trisomy for synaptojanin1 in Down syndrome is functionally linked to the enlargement of early endosomes.

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01 Jan 2012
publication

Homodimerization of amyloid precursor protein at the plasma membrane: a homoFRET study by time-resolved fluorescence anisotropy imaging.

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01 Apr 2011
publication

Local cholesterol increase triggers amyloid precursor protein-Bace1 clustering in lipid rafts and rapid endocytosis.

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01 Aug 2010
publication

Clathrin-dependent APP endocytosis and Abeta secretion are highly sensitive to the level of plasma membrane cholesterol.

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01 Aug 2010
publication

Cholesterol changes in Alzheimer’s disease: methods of analysis and impact on the formation of enlarged endosomes.

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01 Mar 2010
publication

Enrichment of cholesterol in microdissected Alzheimer’s disease senile plaques as assessed by mass spectrometry.

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20 Jan 2009
publication

Time-gated total internal reflection fluorescence microscopy with a supercontinuum excitation source.

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21 May 2006
publication

Mutations in GLIS3 are responsible for a rare syndrome with neonatal diabetes mellitus and congenital hypothyroidism.

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