Timeline

Christian Demeure

Permanent Researcher

16 Jan 2024

patent

Plague vaccine

16 Jan 2024

project

Development of a new vaccine against Plague

16 Jan 2024

team

Immunity against plague and other Yersinioses

07 Apr 2023

publication

Reply to Barton et al: signatures of natural selection during the Black Death.

01 Apr 2023

publication

[The Black Death, natural selection and susceptibility to auto-immune disorders].

01 Apr 2023

publication

Yersinia pestis and plague in the 21st century: learning from a distant past

01 Nov 2022

publication

Evolution of immune genes is associated with the Black Death.

06 Jul 2022

publication

First Description of a Yersinia pseudotuberculosis Clonal Outbreak in France, Confirmed Using a New Core Genome Multilocus Sequence Typing Method.

10 Nov 2020

publication

Short- and long-term humoral immune response against Yersinia pestis in plague patients, Madagascar.

01 Aug 2020

publication

Human plague: An old scourge that needs new answers.

18 Jan 2020

publication

Subcutaneous vaccination with a live attenuated Yersinia pseudotuberculosis plague vaccine

02 Dec 2019

publication

Can we make human plague history? A call to action

01 May 2019

publication

Yersinia pestis and plague: an updated view on evolution, virulence determinants, immune subversion, vaccination, and diagnostics

01 Jan 2019

publication

Yersinia pestis and plague: an updated view on evolution, virulence determinants, immune subversion, vaccination and diagnostics

19 Nov 2018

publication

Humoral and cellular immune correlates of protection against bubonic plague by a live Yersinia pseudotuberculosis vaccine.

15 Sep 2017

publication

Enhanced Macrophage M1 Polarization and Resistance to Apoptosis Enable Resistance to Plague

01 Apr 2016

publication

Oral vaccination against plague using Yersinia pseudotuberculosis

16 Oct 2015

publication

Complete Protection against Pneumonic and Bubonic Plague after a Single Oral Vaccination

11 May 2015

team

Yersinia

29 Jan 2013

publication

Fast and simple detection of Yersinia pestis applicable to field investigation of plague foci

15 Nov 2012

publication

Resistance to plague of Mus spretus SEG/Pas mice requires the combined action of at least four genetic factors

14 Feb 2012

publication

An encapsulated Yersinia pseudotuberculosis is a highly efficient vaccine against pneumonic plague

01 Jan 2012

publication

Live vaccines against Plague and Pseudotuberculosis

16 Nov 2011

publication

Early systemic bacterial dissemination and a rapid innate immune response characterize genetic resistance to plague of SEG mice

06 Jul 2010

publication

Delineation and analysis of chromosomal regions specifying Yersinia pestis

19 Jan 2010

publication

Efficacy of an oral live vaccine for veterinary use against pseudotuberculosis

27 May 2008

publication

Oral vaccination against bubonic plague using a live avirulent Yersinia pseudotuberculosis strain

01 Apr 2005

publication

Anopheles mosquito bites activate cutaneous mast cells leading to a local inflammatory response and lymph node hyperplasia

15 Mar 2003

publication

Mast cell-derived exosomes induce phenotypic and functional maturation of dendritic cells and elicit specific immune responses in vivo

01 Sep 2001

publication

T Lymphocytes infiltrating various tumour types express the MHC class II ligand lymphocyte activation gene-3 (LAG-3): role of LAG-3/MHC class II interactions in cell-cell contacts

01 Sep 2001

publication

Bidirectional negative regulation of human T and dendritic cells by CD47 and its cognate receptor signal-regulator protein-alpha: down-regulation of IL-12 responsiveness and inhibition of dendritic cell activation

01 Aug 2000

publication

Human monocyte-derived dendritic cells induce naive T cell differentiation into T helper cell type 2 (Th2) or Th1/Th2 effectors. Role of stimulator/responder ratio

15 Feb 2000

publication

CD47 engagement inhibits cytokine production and maturation of human dendritic cells

01 Apr 1999

publication

Naive human CD4+ T cells are a major source of lymphotoxin alpha

01 Mar 1999

publication

Lymphocyte activation gene-3, a MHC class II ligand expressed on activated T cells, stimulates TNF-alpha and IL-12 production by monocytes and dendritic cells

01 Feb 1999

publication

OX40-Mediated cosignal enhances the maturation of naive human CD4+ T cells into high IL-4-producing effectors

01 Oct 1998

publication

IL-15 promotes IL-12 production by human monocytes via T cell-dependent contact and may contribute to IL-12-mediated IFN-gamma secretion by CD4+ T cells in the absence of TCR ligation

01 Aug 1998

publication

Maturation of human neonatal CD4+ and CD8+ T lymphocytes into Th1/Th2 effectors

01 Dec 1997

publication

Prostaglandin E2 primes naive T cells for the production of anti-inflammatory cytokines

01 May 1997

publication

In vitro maturation of naive human CD4+ T lymphocytes into Th1, Th2 effectors

01 Dec 1996

publication

Human Th2-like cell clones induce IL-12 production by dendritic cells and may express several cytokine profiles

31 Oct 1996

publication

Role of interleukin-12 in the maturation of naive human CD4 T cells

01 May 1996

publication

CD31 (PECAM-1) is a differentiation antigen lost during human CD4 T-cell maturation into Th1 or Th2 effector cells

01 Dec 1995

publication

Maturation of neonatal human CD4 T cells: III. Role of B7 co-stimulation at priming

01 Dec 1995

publication

Default development of cloned human naive CD4 T cells into interleukin-4- and interleukin-5- producing effector cells

01 Sep 1995

publication

Human naive CD4 T cells produce interleukin-4 at priming and acquire a Th2 phenotype upon repetitive stimulations in neutral conditions

01 Dec 1994

publication

In vitro maturation of neonatal human CD8 T lymphocytes into IL-4- and IL-5-producing cells

01 Oct 1994

publication

Interleukin 12 exerts a differential effect on the maturation of neonatal and adult human CD45R0- CD4 T cells

15 May 1994

publication

In vitro maturation of human neonatal CD4 T lymphocytes. II. Cytokines present at priming modulate the development of lymphokine production

01 Feb 1994

publication

In vitro maturation of human neonatal CD4 T lymphocytes. I. Induction of IL-4-producing cells after long-term culture in the presence of IL-4 plus either IL-2 or IL-12

01 Oct 1993

publication

Resistance to Schistosoma mansoni in humans: influence of the IgE/IgG4 balance and IgG2 in immunity to reinfection after chemotherapy

15 Aug 1993

publication

IL-12 induces the production of IFN-gamma by neonatal human CD4 T cells

01 Jan 1993

publication

Correlation between cell-mediated immunity and degree of infection in subjects living in an endemic area of schistosomiasis

01 Aug 1992

publication

Environmental, genetic and immunological factors in human resistance to Schistosoma mansoni

01 Aug 1992

publication

Strong serum inhibition of specific IgE correlated to competing IgG4, revealed by a new methodology in subjects from a S. mansoni endemic area

01 Nov 1991

publication

Evidence for an association between human resistance to Schistosoma mansoni and high anti-larval IgE levels

15 Apr 1988

publication

Human resistance to Schistosoma mansoni is associated with IgG reactivity to a 37-kDa larval surface antigen

01 Nov 1987

publication

A little guide for advanced search:

Plague vaccine

Development of a new vaccine against Plague

Immunity against plague and other Yersinioses

Reply to Barton et al: signatures of natural selection during the Black Death.

[The Black Death, natural selection and susceptibility to auto-immune disorders].

Yersinia pestis and plague in the 21st century: learning from a distant past

Evolution of immune genes is associated with the Black Death.

First Description of a Yersinia pseudotuberculosis Clonal Outbreak in France, Confirmed Using a New Core Genome Multilocus Sequence Typing Method.

Short- and long-term humoral immune response against Yersinia pestis in plague patients, Madagascar.

Human plague: An old scourge that needs new answers.

Subcutaneous vaccination with a live attenuated Yersinia pseudotuberculosis plague vaccine

﻿Can we make human plague history? A call to action

Yersinia pestis and plague: an updated view on evolution, virulence determinants, immune subversion, vaccination, and diagnostics

Yersinia pestis and plague: an updated view on evolution, virulence determinants, immune subversion, vaccination and diagnostics

Humoral and cellular immune correlates of protection against bubonic plague by a live Yersinia pseudotuberculosis vaccine.

Enhanced Macrophage M1 Polarization and Resistance to Apoptosis Enable Resistance to Plague

Oral vaccination against plague using Yersinia pseudotuberculosis

Complete Protection against Pneumonic and Bubonic Plague after a Single Oral Vaccination

Yersinia

Fast and simple detection of Yersinia pestis applicable to field investigation of plague foci

Resistance to plague of Mus spretus SEG/Pas mice requires the combined action of at least four genetic factors

An encapsulated Yersinia pseudotuberculosis is a highly efficient vaccine against pneumonic plague

Live vaccines against Plague and Pseudotuberculosis

Early systemic bacterial dissemination and a rapid innate immune response characterize genetic resistance to plague of SEG mice

Delineation and analysis of chromosomal regions specifying Yersinia pestis

Efficacy of an oral live vaccine for veterinary use against pseudotuberculosis

Oral vaccination against bubonic plague using a live avirulent Yersinia pseudotuberculosis strain

Anopheles mosquito bites activate cutaneous mast cells leading to a local inflammatory response and lymph node hyperplasia

Mast cell-derived exosomes induce phenotypic and functional maturation of dendritic cells and elicit specific immune responses in vivo

T Lymphocytes infiltrating various tumour types express the MHC class II ligand lymphocyte activation gene-3 (LAG-3): role of LAG-3/MHC class II interactions in cell-cell contacts

Bidirectional negative regulation of human T and dendritic cells by CD47 and its cognate receptor signal-regulator protein-alpha: down-regulation of IL-12 responsiveness and inhibition of dendritic cell activation

Human monocyte-derived dendritic cells induce naive T cell differentiation into T helper cell type 2 (Th2) or Th1/Th2 effectors. Role of stimulator/responder ratio

CD47 engagement inhibits cytokine production and maturation of human dendritic cells

Naive human CD4+ T cells are a major source of lymphotoxin alpha

Lymphocyte activation gene-3, a MHC class II ligand expressed on activated T cells, stimulates TNF-alpha and IL-12 production by monocytes and dendritic cells

OX40-Mediated cosignal enhances the maturation of naive human CD4+ T cells into high IL-4-producing effectors

IL-15 promotes IL-12 production by human monocytes via T cell-dependent contact and may contribute to IL-12-mediated IFN-gamma secretion by CD4+ T cells in the absence of TCR ligation

Maturation of human neonatal CD4+ and CD8+ T lymphocytes into Th1/Th2 effectors

Prostaglandin E2 primes naive T cells for the production of anti-inflammatory cytokines

In vitro maturation of naive human CD4+ T lymphocytes into Th1, Th2 effectors

Human Th2-like cell clones induce IL-12 production by dendritic cells and may express several cytokine profiles

Role of interleukin-12 in the maturation of naive human CD4 T cells

CD31 (PECAM-1) is a differentiation antigen lost during human CD4 T-cell maturation into Th1 or Th2 effector cells

Maturation of neonatal human CD4 T cells: III. Role of B7 co-stimulation at priming

Default development of cloned human naive CD4 T cells into interleukin-4- and interleukin-5- producing effector cells

Human naive CD4 T cells produce interleukin-4 at priming and acquire a Th2 phenotype upon repetitive stimulations in neutral conditions

In vitro maturation of neonatal human CD8 T lymphocytes into IL-4- and IL-5-producing cells

Interleukin 12 exerts a differential effect on the maturation of neonatal and adult human CD45R0- CD4 T cells

In vitro maturation of human neonatal CD4 T lymphocytes. II. Cytokines present at priming modulate the development of lymphokine production

In vitro maturation of human neonatal CD4 T lymphocytes. I. Induction of IL-4-producing cells after long-term culture in the presence of IL-4 plus either IL-2 or IL-12

Resistance to Schistosoma mansoni in humans: influence of the IgE/IgG4 balance and IgG2 in immunity to reinfection after chemotherapy

IL-12 induces the production of IFN-gamma by neonatal human CD4 T cells

Correlation between cell-mediated immunity and degree of infection in subjects living in an endemic area of schistosomiasis

Environmental, genetic and immunological factors in human resistance to Schistosoma mansoni

Strong serum inhibition of specific IgE correlated to competing IgG4, revealed by a new methodology in subjects from a S. mansoni endemic area

Evidence for an association between human resistance to Schistosoma mansoni and high anti-larval IgE levels

Human resistance to Schistosoma mansoni is associated with IgG reactivity to a 37-kDa larval surface antigen

Conformational differences of human IgE on hydrophobic and hydrophilic solid phases detected by monoclonal antibodies

Can we make human plague history? A call to action