Lien vers Pubmed [PMID] – 38865964
Lien DOI – 10.1016/j.immuni.2024.05.013
Immunity 2024 Jun; 57(6): 1189-1191
Phagocytic microglia such as proliferative region-associated microglia and disease-associated microglia appear in the brain transiently during development and across various brain pathologies, but their function and degree of plasticity remain unclear. In this issue of Immunity, Barclay et al. established a novel Clec7a-CreERT2 mouse line to uncover the plasticity of this cell state and its role in a model of myelin injury.