Deficiency of the LIM-only protein FHL2 reduces intestinal tumorigenesis in Apc mutant mice

Lien vers Pubmed [PMID] – 20442768

PLoS ONE 2010;5(4):e10371

The four and a half LIM-only protein 2 (FHL2) is capable of shuttling between focal adhesion and nucleus where it signals through direct interaction with a number of proteins including beta-catenin. Although FHL2 activation has been found in various human cancers, evidence of its functional contribution to carcinogenesis has been lacking.