• 2024
  Dulon D, de Monvel JB, Plion B, Mallet A, Petit C, Condamine S, Bouleau Y, Safieddine S, A free intravesicular C-terminal of otoferlin is essential for synaptic vesicle docking and fusion at auditory inner hair cell ribbon synapses., Prog Neurobiol 2024 Aug; 240(): 102658.
• 2024
  Ghizlene Lahlou, Charlotte Calvet, François Simon, Vincent Michel, Lauranne Alciato, Baptiste Plion, Jacques Boutet de Monvel, Marie-José Lecomte, Mathieu Beraneck, Christine Petit, Saaid Safieddine, Extended time frame for restoring inner ear function through gene therapy in Usher1G preclinical model, JCI Insight, 2024, 9 (3), pp.e169504. ⟨10.1172/jci.insight.169504⟩.
• 2023
  Jean P, Wong Jun Tai F, Singh-Estivalet A, Lelli A, Scandola C, Megharba S, Schmutz S, Roux S, Mechaussier S, Sudres M, Mouly E, Heritier AV, Bonnet C, Mallet A, Novault S, Libri V, Petit C, Michalski N, Single-cell transcriptomic profiling of the mouse cochlea: An atlas for targeted therapies., Proc Natl Acad Sci U S A 2023 Jun; 120(26): e2221744120.
• 2022
  Calvet C, Peineau T, Benamer N, Cornille M, Lelli A, Plion B, Lahlou G, Fanchette J, Nouaille S, Boutet de Monvel J, Estivalet A, Jean P, Michel V, Sachse M, Michalski N, Avan P, Petit C, Dulon D, Safieddine S, The SNARE protein SNAP-25 is required for normal exocytosis at auditory hair cell ribbon synapses., iScience 2022 Dec; 25(12): 105628.
• 2020
  Boucher S, Tai FWJ, Delmaghani S, Lelli A, Singh-Estivalet A, Dupont T, Niasme-Grare M, Michel V, Wolff N, Bahloul A, Bouyacoub Y, Bouccara D, Fraysse B, Deguine O, Collet L, Thai-Van H, Ionescu E, Kemeny JL, Giraudet F, Lavieille JP, Devèze A, Roudevitch-Pujol AL, Vincent C, Renard C, Franco-Vidal V, Thibult-Apt C, Darrouzet V, Bizaguet E, Coez A, Aschard H, Michalski N, Lefevre GM, Aubois A, Avan P, Bonnet C, Petit C, , Ultrarare heterozygous pathogenic variants of genes causing dominant forms of early-onset deafness underlie severe presbycusis., Proc Natl Acad Sci U S A 2020 12; 117(49): 31278-31289.
• 2016
  Crystel Bonnet, Zied Riahi, Sandra Chantot-Bastaraud, Luce Smagghe, Mélanie Letexier, Charles Marcaillou, Gaëlle Lefèvre, Jean-Pierre Hardelin, Aziz El-Amraoui, Amrit Singh-Estivalet, Saddek Mohand-Saïd, Susanne Kohl, Anne Kurtenbach, Ieva Sliesoraityte, Ditta Zobor, Souad Gherbi, Francesco Testa, Francesca Simonelli, Sandro Banfi, Ana Fakin, Damjan Glavač, Martina Jarc-Vidmar, Andrej Zupan, Saba Battelino, Loreto Martorell Sampol, Maria Antonia Claveria, Jaume Catala Mora, Shzeena Dad, Lisbeth Møller, Jesus Rodriguez Jorge, Marko Hawlina, Alberto Auricchio, José-Alain Sahel, Sandrine Marlin, Eberhart Zrenner, Isabelle Audo, Christine Petit, An innovative strategy for the molecular diagnosis of Usher syndrome identifies causal biallelic mutations in 93% of European patients, European Journal of Human Genetics, 2016, 24 (12), pp.1730-1738. ⟨10.1038/ejhg.2016.99⟩.
• 2016
  Zhang QJ, Han B, Lan L, Zong L, Shi W, Wang HY, Xie LY, Wang H, Zhao C, Zhang C, Yin ZF, Wang DY, Petit C, Guan J, Wang QJ, High frequency of OTOF mutations in Chinese infants with congenital auditory neuropathy spectrum disorder, Clin. Genet. 2016 Jan;.
• 2016
  Andrea Lelli, Vincent Michel, Jacques Boutet de Monvel, Matteo Cortese, Montserrat Bosch-Grau, Asadollah Aghaie, Isabelle Perfettini, Typhaine Dupont, Paul Avan, Aziz El-Amraoui, Christine Petit, Class III myosins shape the auditory hair bundles by limiting microvilli and stereocilia growth., Journal of Cell Biology, 2016, 212 (2), pp.231-44. ⟨10.1083/jcb.201509017⟩.
• 2015
  Vincent PF, Bouleau Y, Petit C, Dulon D, A synaptic F-actin network controls otoferlin-dependent exocytosis in auditory inner hair cells, Elife 2015;4.
• 2015
  Delmaghani S, Defourny J, Aghaie A, Beurg M, Dulon D, Thelen N, Perfettini I, Zelles T, Aller M, Meyer A, Emptoz A, Giraudet F, Leibovici M, Dartevelle S, Soubigou G, Thiry M, Vizi ES, Safieddine S, Hardelin JP, Avan P, Petit C, Hypervulnerability to Sound Exposure through Impaired Adaptive Proliferation of Peroxisomes., Cell 2015 Nov; 163(4): 894-906.
• 2015
  Dahmani M, Ammar-Khodja F, Bonnet C, Lefèvre GM, Hardelin JP, Ibrahim H, Mallek Z, Petit C, EPS8L2 is a new causal gene for childhood onset autosomal recessive progressive hearing loss, Orphanet J Rare Dis 2015;10:96.
• 2015
  Pepermans E, Petit C, The tip-link molecular complex of the auditory mechano-electrical transduction machinery, Hear. Res. 2015 Dec;330(Pt A):10-7.
• 2015
  Zong L, Guan J, Ealy M, Zhang Q, Wang D, Wang H, Zhao Y, Shen Z, Campbell CA, Wang F, Yang J, Sun W, Lan L, Ding D, Xie L, Qi Y, Lou X, Huang X, Shi Q, Chang S, Xiong W, Yin Z, Yu N, Zhao H, Wang J, Wang J, Salvi RJ, Petit C, Smith RJ, Wang Q, Mutations in apoptosis-inducing factor cause X-linked recessive auditory neuropathy spectrum disorder, J. Med. Genet. 2015 May;.
• 2015
  Riahi Z, Bonnet C, Zainine R, Lahbib S, Bouyacoub Y, Bechraoui R, Marrakchi J, Hardelin JP, Louha M, Largueche L, Ben Yahia S, Kheirallah M, Elmatri L, Besbes G, Abdelhak S, Petit C, Whole exome sequencing identifies mutations in Usher syndrome genes in profoundly deaf Tunisian patients, PLoS ONE 2015;10(3):e0120584.
• 2015
  Ammar-Khodja F, Bonnet C, Dahmani M, Ouhab S, Lefèvre GM, Ibrahim H, Hardelin JP, Weil D, Louha M, Petit C, Diversity of the causal genes in hearing impaired Algerian individuals identified by whole exome sequencing, Mol Genet Genomic Med 2015 May;3(3):189-96.
• 2014
  Wang H, Zhao Y, Yi Y, Gao Y, Liu Q, Wang D, Li Q, Lan L, Li N, Guan J, Yin Z, Han B, Zhao F, Zong L, Xiong W, Yu L, Song L, Yi X, Yang L, Petit C, Wang Q, Targeted high-throughput sequencing identifies pathogenic mutations in KCNQ4 in two large Chinese families with autosomal dominant hearing loss, PLoS ONE 2014;9(8):e103133.
• 2014
  Romdhane L, Ben Halim N, Rejeb I, Kefi R, Bouyacoub Y, Ben Rekaya M, Messai H, Messaoud O, Riahi Z, Bonnet C, Ben Rhouma F, Nagara M, Petit C, McElreavey K, Romeo G, Abdelhak S, Specific aspects of consanguinity: some examples from the Tunisian population, Hum. Hered. 2014;77(1-4):167-74.
• 2014
  Michalski N, Petit C, Genetics of auditory mechano-electrical transduction, Pflugers Arch. 2015 Jan;467(1):49-72.
• 2014
  Pepermans E, Michel V, Goodyear R, Bonnet C, Abdi S, Dupont T, Gherbi S, Holder M, Makrelouf M, Hardelin JP, Marlin S, Zenati A, Richardson G, Avan P, Bahloul A, Petit C, The CD2 isoform of protocadherin-15 is an essential component of the tip-link complex in mature auditory hair cells, EMBO Mol Med 2014 Jul;6(7):984-92.
• 2014
  Riahi Z, Bonnet C, Zainine R, Louha M, Bouyacoub Y, Laroussi N, Chargui M, Kefi R, Jonard L, Dorboz I, Hardelin JP, Salah SB, Levilliers J, Weil D, McElreavey K, Boespflug OT, Besbes G, Abdelhak S, Petit C, Whole exome sequencing identifies new causative mutations in Tunisian families with non-syndromic deafness, PLoS ONE 2014;9(6):e99797.
• 2014
  Behlouli A, Bonnet C, Abdi S, Bouaita A, Lelli A, Hardelin JP, Schietroma C, Rous Y, Louha M, Cheknane A, Lebdi H, Boudjelida K, Makrelouf M, Zenati A, Petit C, EPS8, encoding an actin-binding protein of cochlear hair cell stereocilia, is a new causal gene for autosomal recessive profound deafness, Orphanet J Rare Dis 2014;9:55.
• 2014
  Aziz El-Amraoui, Christine Petit, The retinal phenotype of Usher syndrome: Pathophysiological insights from animal models Atteinte rétinienne dans le syndrome de Usher : contribution des modèles animaux à la physiopathologie, Comptes Rendus. Biologies, 2014, 337 (3), pp.167 - 177. ⟨10.1016/j.crvi.2013.12.004⟩.
• 2013
  Meyer A, Petit C, Safieddine S, [Gene therapy for human hearing loss: challenges and promises]., Med Sci (Paris) 2013 Oct; 29(10): 883-9.
• 2013
  Samantha Papal, Matteo Cortese, Kirian Legendre, Nasrin Sorusch, Joseph Dragavon, Iman Sahly, Spencer Shorte, Uwe Wolfrum, Christine Petit, Aziz El-Amraoui, The giant spectrin βV couples the molecular motors to phototransduction and Usher syndrome type I proteins along their trafficking route, Human Molecular Genetics, 2013, 22 (18), pp.3773 - 3788. ⟨10.1093/hmg/ddt228⟩.
• 2013
  Lepelletier L, de Monvel JB, Buisson J, Desdouets C, Petit C, Auditory hair cell centrioles undergo confined Brownian motion throughout the developmental migration of the kinocilium, Biophys. J. 2013 Jul;105(1):48-58.
• 2012
  Delmaghani S, Aghaie A, Michalski N, Bonnet C, Weil D, Petit C, Defect in the gene encoding the EAR/EPTP domain-containing protein TSPEAR causes DFNB98 profound deafness, Hum. Mol. Genet. 2012 Sep;21(17):3835-44.
• 2011
  Caberlotto E, Michel V, Foucher I, Bahloul A, Goodyear RJ, Pepermans E, Michalski N, Perfettini I, Alegria-Prévot O, Chardenoux S, Do Cruzeiro M, Hardelin JP, Richardson GP, Avan P, Weil D, Petit C, Usher type 1G protein sans is a critical component of the tip-link complex, a structure controlling actin polymerization in stereocilia, Proc. Natl. Acad. Sci. U.S.A. 2011 Apr;108(14):5825-30.
• 2011
  Verpy E, Leibovici M, Michalski N, Goodyear RJ, Houdon C, Weil D, Richardson GP, Petit C, Stereocilin connects outer hair cell stereocilia to one another and to the tectorial membrane, J. Comp. Neurol. 2011 Feb;519(2):194-210.
• 2010
  Bahloul A, Michel V, Hardelin JP, Nouaille S, Hoos S, Houdusse A, England P, Petit C, Cadherin-23, myosin VIIa and harmonin, encoded by Usher syndrome type I genes, form a ternary complex and interact with membrane phospholipids, Hum. Mol. Genet. 2010 Sep;19(18):3557-65.
• 2010
  Boutet de Monvel J, Petit C, Wrapping up stereocilia rootlets, Cell 2010 May;141(5):748-50.
• 2010
  Etournay R, Lepelletier L, Boutet de Monvel J, Michel V, Cayet N, Leibovici M, Weil D, Foucher I, Hardelin JP, Petit C, Cochlear outer hair cells undergo an apical circumference remodeling constrained by the hair bundle shape, Development 2010 Apr;137(8):1373-83.
• 2009
  Roux I, Hosie S, Johnson SL, Bahloul A, Cayet N, Nouaille S, Kros CJ, Petit C, Safieddine S, Myosin VI is required for the proper maturation and function of inner hair cell ribbon synapses., Hum Mol Genet 2009 Dec; 18(23): 4615-28.
• 2009
  del Castillo FJ, Cohen-Salmon M, Charollais A, Caille D, Lampe PD, Chavrier P, Meda P, Petit C, Consortin, a trans-Golgi network cargo receptor for the plasma membrane targeting and recycling of connexins, Hum. Mol. Genet. 2010 Jan;19(2):262-75.
• 2009
  Petit C, Richardson GP, Linking genes underlying deafness to hair-bundle development and function, Nat. Neurosci. 2009 Jun;12(6):703-10.
• 2009
  Bahloul A, Simmler MC, Michel V, Leibovici M, Perfettini I, Roux I, Weil D, Nouaille S, Zuo J, Zadro C, Licastro D, Gasparini P, Avan P, Hardelin JP, Petit C, Vezatin, an integral membrane protein of adherens junctions, is required for the sound resilience of cochlear hair cells, EMBO Mol Med 2009 May;1(2):125-38.
• 2008
  Verpy E, Weil D, Leibovici M, Goodyear RJ, Hamard G, Houdon C, Lefèvre GM, Hardelin JP, Richardson GP, Avan P, Petit C, Stereocilin-deficient mice reveal the origin of cochlear waveform distortions, Nature 2008 Nov;456(7219):255-8.
• 2008
  Lefèvre G, Michel V, Weil D, Lepelletier L, Bizard E, Wolfrum U, Hardelin JP, Petit C, A core cochlear phenotype in USH1 mouse mutants implicates fibrous links of the hair bundle in its cohesion, orientation and differential growth, Development 2008 Apr;135(8):1427-37.
• 2008
  Michel Leibovici, Saaid Safieddine, Christine Petit, [Chapter 8] Mouse Models for Human Hereditary Deafness, Mouse Models of Developmental Genetic Disease, 84, Elsevier, pp.385-429, 2008, Current Topics in Developmental Biology, 978-0-12-374454-8. ⟨10.1016/S0070-2153(08)00608-X⟩.
• 2007
  Michalski N, Michel V, Bahloul A, Lefèvre G, Barral J, Yagi H, Chardenoux S, Weil D, Martin P, Hardelin JP, Sato M, Petit C, Molecular characterization of the ankle-link complex in cochlear hair cells and its role in the hair bundle functioning., J Neurosci 2007 Jun; 27(24): 6478-88.
• 2006
  Roux I, Safieddine S, Nouvian R, Grati M, Simmler MC, Bahloul A, Perfettini I, Le Gall M, Rostaing P, Hamard G, Triller A, Avan P, Moser T, Petit C, Otoferlin, defective in a human deafness form, is essential for exocytosis at the auditory ribbon synapse., Cell 2006 Oct; 127(2): 277-89.
• 2006
  Petit C, From deafness genes to hearing mechanisms: harmony and counterpoint, Trends Mol Med 2006 Feb;12(2):57-64.
• 2005
  Raphael Etournay, Aziz El-Amraoui, Amel Bahloul, Stéphane Blanchard, Isabelle Roux, Guillaume Pézeron, Nicolas Michalski, Laurent Daviet, Jean-Pierre Hardelin, Pierre Legrain, Christine Petit, PHR1, an integral membrane protein of the inner ear sensory cells, directly interacts with myosin 1c and myosin VIIa., Journal of Cell Science, 2005, 118 (13), pp.2891-99. ⟨10.1242/jcs.02424⟩.
• 2005
  Leibovici M, Verpy E, Goodyear RJ, Zwaenepoel I, Blanchard S, Lainé S, Richardson GP, Petit C, Initial characterization of kinocilin, a protein of the hair cell kinocilium, Hear. Res. 2005 May;203(1-2):144-53.
• 2005
  Michel V, Goodyear RJ, Weil D, Marcotti W, Perfettini I, Wolfrum U, Kros CJ, Richardson GP, Petit C, Cadherin 23 is a component of the transient lateral links in the developing hair bundles of cochlear sensory cells, Dev. Biol. 2005 Apr;280(2):281-94.
• 2005
  Benjamin Delprat, Vincent Michel, Richard Goodyear, Yasuhiro Yamasaki, Nicolas Michalski, Aziz El-Amraoui, Isabelle Perfettini, Pierre Legrain, Guy Richardson, Jean-Pierre Hardelin, Christine Petit, Myosin XVa and whirlin, two deafness gene products required for hair bundle growth, are located at the stereocilia tips and interact directly, Human Molecular Genetics, 2004, 14 (3), pp.401 - 410. ⟨10.1093/hmg/ddi036⟩.
• 2004
  Petit C, Memorial lecture-hereditary sensory defects: from genes to pathogenesis, Am. J. Med. Genet. A 2004 Sep;130A(1):3-7.
• 2004
  Sandra Sousa, Didier Cabanes, Aziz El-Amraoui, Christine Petit, Marc Lecuit, Pascale Cossart, Unconventional myosin VIIa and vezatin, two proteins crucial for Listeria entry into epithelial cells, Journal of Cell Science, 2004, 117 (Pt 10), pp.2121-2130. ⟨10.1242/jcs.01066⟩.
• 2004
  Hardelin JP, Denoyelle F, Levilliers J, Simmler MC, Petit C, [Hereditary deafness: molecular genetics], Med Sci (Paris) 2004 Mar;20(3):311-6.
• 2004
  Cohen-Salmon M, Maxeiner S, Krüger O, Theis M, Willecke K, Petit C, Expression of the connexin43- and connexin45-encoding genes in the developing and mature mouse inner ear, Cell Tissue Res. 2004 Apr;316(1):15-22.
• 2003
  Delmaghani S, Aghaie A, Compain-Nouaille S, Ataie A, Lemainque A, Zeinali S, Lathrop M, Weil D, Petit C, DFNB40, a recessive form of sensorineural hearing loss, maps to chromosome 22q11.21-12.1, Eur. J. Hum. Genet. 2003 Oct;11(10):816-8.
• 2002
  Cohen-Salmon M, Ott T, Michel V, Hardelin JP, Perfettini I, Eybalin M, Wu T, Marcus DC, Wangemann P, Willecke K, Petit C, Targeted ablation of connexin26 in the inner ear epithelial gap junction network causes hearing impairment and cell death, Curr. Biol. 2002 Jul;12(13):1106-11.
• 2002
  Coimbra RS, Weil D, Brottier P, Blanchard S, Levi M, Hardelin JP, Weissenbach J, Petit C, A subtracted cDNA library from the zebrafish (Danio rerio) embryonic inner ear, Genome Res. 2002 Jun;12(6):1007-11.
• 2002
  Soussi-Yanicostas N, de Castro F, Julliard AK, Perfettini I, Chédotal A, Petit C, Anosmin-1, defective in the X-linked form of Kallmann syndrome, promotes axonal branch formation from olfactory bulb output neurons, Cell 2002 Apr;109(2):217-28.
• 2002
  El-Amraoui A, Schonn JS, Küssel-Andermann P, Blanchard S, Desnos C, Henry JP, Wolfrum U, Darchen F, Petit C, , MyRIP, a novel Rab effector, enables myosin VIIa recruitment to retinal melanosomes., EMBO Rep 2002 May; 3(5): 463-70.
• 2002
  Mustapha M, Chouery E, Torchard-Pagnez D, Nouaille S, Khrais A, Sayegh FN, Mégarbané A, Loiselet J, Lathrop M, Petit C, Weil D, A novel locus for Usher syndrome type I, USH1G, maps to chromosome 17q24-25, Hum. Genet. 2002 Apr;110(4):348-50.
• 2002
  Mustapha M, Chouery E, Chardenoux S, Naboulsi M, Paronnaud J, Lemainque A, Mégarbané A, Loiselet J, Weil D, Lathrop M, Petit C, DFNB31, a recessive form of sensorineural hearing loss, maps to chromosome 9q32-34, Eur. J. Hum. Genet. 2002 Mar;10(3):210-2.
• 2002
  Denoyelle F, Mustapha M, Petit C, DFNB21, Adv. Otorhinolaryngol. 2002;61:153-5.
• 2002
  Denoyelle F, Petit C, DFNB9, Adv. Otorhinolaryngol. 2002;61:142-4.