Présentation
![](https://research.pasteur.fr/wp-content/uploads/2015/07/research_pasteur-dna-polymerases-engineering-and-synthetic-biology-polb-hna-300x254.jpg)
We work with archaeal DNA polymerases (PolB) that were evolved to accept xeno-nucleotides to understand the molecular basis of their changed specificity. We use this information to engineer new DNA polymerases to synthesize variants of DNA and RNA.