Lien vers Pubmed [PMID] – 33881354
Lien DOI – 10.1152/ajpgi.00028.2021
Am J Physiol Gastrointest Liver Physiol 2021 Jun; 320(6): G1014-G1033
Selecting the most relevant control diet is of critical importance for metabolic and intestinal studies in animal models. Chow and LF-purified diet differentially impact metabolic and gut microbiome outcomes resulting in major changes in intestinal integrity in LF-fed animals which contributes to altering metabolic homeostasis. Dietary fat and low fiber both contribute to the deleterious metabolic effect of purified HF diets through both selective and overlapping mechanisms.