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© Christine Schmitt, Meriem El Ghachi, Jean-Marc Panaud
Bactérie Helicobacter pylori en microscopie électronique à balayage. Agent causal de pathologies de l'estomac : elle est responsable des gastrites chroniques, d'ulcères gastriques et duodénaux et elle joue un rôle important dans la genèse des cancers gastriques (adénocarcinomes et lymphomes).
Publication : Oncoimmunology

Why should we need the gut microbiota to respond to cancer therapies?

Team: Biology and Genetics of Bacterial Cell Wall
Member: Ivo Gomperts Boneca
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Oncoimmunology - 17 Jan 2014

Viaud S, Daillère R, Yamazaki T, Lepage P, Boneca I, Goldszmid R, Trinchieri G, Zitvogel L

Link to Pubmed [PMID] – 24800167

Oncoimmunology 2014 Jan;3(1):e27574

Cyclophosphamide, one of the most efficient tumoricidal, antiangiogenic, and immunostimulatory drugs employed to date mediates part of its effects through intestinal bacteria, against which the host becomes immunized during treatment. Our recent work suggests that anti-commensal effector pTH17 and memory TH1 CD4(+) T-cell responses are indispensable for optimal anticancer effects as mediated by cyclophosphamide.