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© Research
Publication :

WED-475 Optimal strategies for eliminating mother-to-child transmission of hepatitis B in Burkina Faso

Team: Epidemiology of Emerging Diseases
Member: Andréa GOSSET
Member: Yusuke Shimakawa
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in - 05 Jun 2024

Andréa Gosset, Shevanthi Nayagam, Sylvie Boyer, Alice Guingané, Nora Schmit, Abdoul Salam Eric Tiendrebeogo, Dramane Kania, Patrizia Carrieri, Yusuke Shimakawa, Timothy Hallett

Link to HAL – inserm-05002753

Link to DOI – 10.1016/S0168-8278(24)01941-X

EASL Congress 2024, Jun 2024, Milan, Italy. 80, pp.S678-S679, 2024, ⟨10.1016/S0168-8278(24)01941-X⟩

The baseline strategy was the current situation where HepB-BD is administrated alongside HepB3. Costs were assessed from the Burkina Faso government’s perspective, including costs of intervention strategies, HBV vaccination with the birth dose (HepB-BD), and care for advanced HBV disease. A deterministic compartmental dynamic model stratified by age, sex, and transmission mode was used. An epidemiological model implemented the strategies from 2024 to 2124, while a cost-effectiveness model included strategy implementation in 2024 with a health impact assessment over a 100-year horizon. The cost-effectiveness threshold was half of 2022 GDP per capita (US$416.5) and the discount rate was 3%. Deterministic and probabilistic sensitivity analyses were conducted.

Conclusions

The Treat All strategy was the optimal strategy to eliminate HBV MTCT as quickly as possible.