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© Research
Publication : Science (New York, N.Y.)

Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors

Team: Perception & Action
Member: Lida Katsimpardi
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Science (New York, N.Y.) - 05 May 2014

Katsimpardi L, Litterman NK, Schein PA, Miller CM, Loffredo FS, Wojtkiewicz GR, Chen JW, Lee RT, Wagers AJ, Rubin LL

Link to Pubmed [PMID] – 24797482

Science 2014 May;344(6184):630-4

In the adult central nervous system, the vasculature of the neurogenic niche regulates neural stem cell behavior by providing circulating and secreted factors. Age-related decline of neurogenesis and cognitive function is associated with reduced blood flow and decreased numbers of neural stem cells. Therefore, restoring the functionality of the niche should counteract some of the negative effects of aging. We show that factors found in young blood induce vascular remodeling, culminating in increased neurogenesis and improved olfactory discrimination in aging mice. Further, we show that GDF11 alone can improve the cerebral vasculature and enhance neurogenesis. The identification of factors that slow the age-dependent deterioration of the neurogenic niche in mice may constitute the basis for new methods of treating age-related neurodegenerative and neurovascular diseases.