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© Research
Publication : The Journal of general virology

Variations in prion protein and glial fibrillary acidic protein mRNAs in the brain of scrapie-infected newborn mouse

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in The Journal of general virology - 01 Jul 1992

Lazarini F, Deslys JP, Dormont D

Link to Pubmed [PMID] – 1352797

J. Gen. Virol. 1992 Jul;73 ( Pt 7):1645-8

To begin to understand the molecular basis of cases of Creutzfeldt-Jakob disease recently described in young children, the expression of prion protein and glial fibrillary acidic protein (GFAP) mRNAs was investigated during the development of the brain of scrapie-infected newborn mice. Changes in the time course of expression were identified by Northern blot quantification between days 1 and 172. Although scrapie-infected and control animals showed no detectable changes in brain development (first 56 days of life), GFAP mRNAs were found to increase significantly as early as day 84. A 10-fold increase in the level of GFAP mRNA was observed in brain between day 112 and death (day 172).