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© Research
Publication : American Journal of Tropical Medicine and Hygiene

Variation in Pyrethroid Resistance Phenotypes in Anopheles darlingi in an Area with Residual Malaria Transmission: Warning of Suspected Resistance in French Guiana

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in American Journal of Tropical Medicine and Hygiene - 01 Feb 2023

Samuel Vezenegho, Romuald Carinci, Jean Issaly, Christophe Nguyen, Pascal Gaborit, Laetitia Ferraro, Guillaume Lacour, Emilie Mosnier, Vincent Pommier de Santi, Yanouk Epelboin, Romain Girod, Sebastien Briolant, I. Dusfour

Link to HAL – amu-04115566

Link to DOI – 10.4269/ajtmh.20-1611

American Journal of Tropical Medicine and Hygiene, 2023, 108 (2), pp.424-427. ⟨10.4269/ajtmh.20-1611⟩

ABSTRACT. Anopheles darlingi is the main vector of malaria in South America. In French Guiana, malaria transmission occurs inland and along the rivers with a regular reemergence in the lower Oyapock area. Control against malaria vectors includes indoor residual spraying of deltamethrin and the distribution of long-lasting impregnated bednets. In this context, the level of resistance to pyrethroids was monitored for 4 years using CDC bottle tests in An. darlingi populations. A loss of susceptibility to pyrethroids was recorded with 30-minute knock-down measured as low as 81%. However, no pyrethroid molecular resistance was found by sequencing a 170 base pair fragment of the S6 segment of domain II of the voltage-gated sodium channel gene. Fluctuation of resistance phenotypes may be influenced by the reintroduction of susceptible alleles from sylvatic populations or by other mechanisms of metabolic resistance.